Abstract
Apoptosis is natural process in the development and maintenance of multicellular organisms. However, tumor cells often have faulty apoptotic pathways. The defects of apoptosis are partially caused by mutation and aberrant expression of apoptotic proteins. The apoptosis inactivation is implicated with both tumorigenesis and drug resistance. In addition, as compared to small-cell lung cancers, non-small cell lung cancers are less sensitive to radiation treatment or chemotherapy. Therefore, understanding the mechanisms of apoptosis induction in lung cancer cells is very important for anti-lung cancer drug development and lung cancer therapy. In this review, we discussed about the apoptosis mechanisms and altered apoptosis regulators expression and gene mutation in lung cancer.
Keywords: Lung cancer, apoptosis, anticancer agent
Anti-Cancer Agents in Medicinal Chemistry
Title: Apoptosis and Apoptosis-Based Therapy in Lung Cancer
Volume: 9 Issue: 9
Author(s): Cheng-Xiong Xu, Hua Jin and Myung-Haing Cho
Affiliation:
Keywords: Lung cancer, apoptosis, anticancer agent
Abstract: Apoptosis is natural process in the development and maintenance of multicellular organisms. However, tumor cells often have faulty apoptotic pathways. The defects of apoptosis are partially caused by mutation and aberrant expression of apoptotic proteins. The apoptosis inactivation is implicated with both tumorigenesis and drug resistance. In addition, as compared to small-cell lung cancers, non-small cell lung cancers are less sensitive to radiation treatment or chemotherapy. Therefore, understanding the mechanisms of apoptosis induction in lung cancer cells is very important for anti-lung cancer drug development and lung cancer therapy. In this review, we discussed about the apoptosis mechanisms and altered apoptosis regulators expression and gene mutation in lung cancer.
Export Options
About this article
Cite this article as:
Xu Cheng-Xiong, Jin Hua and Cho Myung-Haing, Apoptosis and Apoptosis-Based Therapy in Lung Cancer, Anti-Cancer Agents in Medicinal Chemistry 2009; 9 (9) . https://dx.doi.org/10.2174/187152009789377682
DOI https://dx.doi.org/10.2174/187152009789377682 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Targeting Kruppel-Like Factor 5 (KLF5) for Cancer Therapy
Current Topics in Medicinal Chemistry Hypertension, Anti-Hypertensive Therapy and Neoplasia
Current Pharmaceutical Design Editorial [Hot topic:Thromboembolism in Patients with Malignancy (Guest Editor: Ioannis Starakis)]
Cardiovascular & Hematological Disorders-Drug Targets Molecular Markers of Angiogenesis and Metastasis in Lines of Oral Carcinoma after Treatment with Melatonin
Anti-Cancer Agents in Medicinal Chemistry Computational Studies in Drug Design Against Cancer
Anti-Cancer Agents in Medicinal Chemistry Drugs that Inhibit Tubulin Polymerization: The Particular Case of Podophyllotoxin and Analogues
Current Medicinal Chemistry - Anti-Cancer Agents Screening of Antioxidant, Antimicrobial Activities and Chemical Contents of Edible Mushrooms Wildly Grown in the Black Sea Region of Turkey
Combinatorial Chemistry & High Throughput Screening A Filter Based Feature Selection Algorithm Using Null Space of Covariance Matrix for DNA Microarray Gene Expression Data
Current Bioinformatics Monoclonal Antibodies in the Treatment of Multiple Sclerosis
Current Medicinal Chemistry Development of Radicicol Analogues
Current Cancer Drug Targets MicroRNA Dysregulation in the Myelodysplastic Syndromes
MicroRNA Carotenoids of Microalgae Used in Food Industry and Medicine
Mini-Reviews in Medicinal Chemistry PET Molecular Imaging of Hypoxia in Ischemic Stroke: An Update
Current Vascular Pharmacology Neobavaisoflavone Demonstrates Valid Anti-tumor Effects in Non-Small- Cell Lung Cancer by Inhibiting STAT3
Combinatorial Chemistry & High Throughput Screening Decreased Parathyroid Hormone Levels Despite Persistent Hypocalcemia in Patients with Kidney Failure Recovering from Septic Shock
Endocrine, Metabolic & Immune Disorders - Drug Targets From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment
Anti-Cancer Agents in Medicinal Chemistry Developing Antitumor Magnetic Hyperthermia: Principles, Materials and Devices
Recent Patents on Anti-Cancer Drug Discovery Ras-Induced Senescence and its Physiological Relevance in Cancer
Current Cancer Drug Targets (+)- and (-)-Itampolin A: First Total Synthesis, Anticancer Effect Through Inhibition of Phospho p38 Expression
Current Organic Synthesis MutS Homologues hMSH4 and hMSH5: Genetic Variations, Functions, and Implications in Human Diseases
Current Genomics