Abstract
The 8H-thieno[2,3-b]pyrrolizinones, some of which exert very potent cytotoxic activity against tumor cell lines in vitro, are a promising novel series of anti-cancer agents. These compounds belong to the tripentone family and are based on 9H-pyrrolo[1,2-a]indol- 9-one derivatives and their heterocyclic isosteres. This paper inventories the different synthetic strategies for tripentones and reviews their biological effects and therapeutic potential.
Keywords: Tripentone, pyrrolizinone, pyrroloindolone, thiophene, cancer
Anti-Cancer Agents in Medicinal Chemistry
Title: Tripentones: A Promising Series of Potent Anti-Cancer Agents
Volume: 9 Issue: 4
Author(s): Christophe Rochais, Patrick Dallemagne and Sylvain Rault
Affiliation:
Keywords: Tripentone, pyrrolizinone, pyrroloindolone, thiophene, cancer
Abstract: The 8H-thieno[2,3-b]pyrrolizinones, some of which exert very potent cytotoxic activity against tumor cell lines in vitro, are a promising novel series of anti-cancer agents. These compounds belong to the tripentone family and are based on 9H-pyrrolo[1,2-a]indol- 9-one derivatives and their heterocyclic isosteres. This paper inventories the different synthetic strategies for tripentones and reviews their biological effects and therapeutic potential.
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Cite this article as:
Rochais Christophe, Dallemagne Patrick and Rault Sylvain, Tripentones: A Promising Series of Potent Anti-Cancer Agents, Anti-Cancer Agents in Medicinal Chemistry 2009; 9 (4) . https://dx.doi.org/10.2174/1871520610909040369
DOI https://dx.doi.org/10.2174/1871520610909040369 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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