Abstract
The identification of a CDC25 inhibitor to arrest the cell cycle closely followed the discovery of CDC25 by Russell and Nurse in 1986. Recent advances at the preclinical and clinical stages reinforce the rationale to consider CDC25 as a relevant target for a cancer treatment. Here, in order to exemplify recent drug discovery efforts, we present our own experience with various chemical series of CDC25 inhibitors. We discuss how we have progressed and how we are considering the next steps to define the clinical entry points and hopefully complete this target validation to generate a new class of therapeutic agents.
Keywords: Cancer, phosphatase, CDC25, inhibitors, cell cycle, proliferation, agents, small molecules
Anti-Cancer Agents in Medicinal Chemistry
Title: CDC25 Inhibitors as Anticancer Agents Are Moving Forward
Volume: 8 Issue: 8
Author(s): M.-C. Brezak, P. G. Kasprzyk, M.-O. Galcera, O. Lavergne and G. P. Prevost
Affiliation:
Keywords: Cancer, phosphatase, CDC25, inhibitors, cell cycle, proliferation, agents, small molecules
Abstract: The identification of a CDC25 inhibitor to arrest the cell cycle closely followed the discovery of CDC25 by Russell and Nurse in 1986. Recent advances at the preclinical and clinical stages reinforce the rationale to consider CDC25 as a relevant target for a cancer treatment. Here, in order to exemplify recent drug discovery efforts, we present our own experience with various chemical series of CDC25 inhibitors. We discuss how we have progressed and how we are considering the next steps to define the clinical entry points and hopefully complete this target validation to generate a new class of therapeutic agents.
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Cite this article as:
Brezak M.-C., Kasprzyk G. P., Galcera M.-O., Lavergne O. and Prevost P. G., CDC25 Inhibitors as Anticancer Agents Are Moving Forward, Anti-Cancer Agents in Medicinal Chemistry 2008; 8 (8) . https://dx.doi.org/10.2174/187152008786847701
DOI https://dx.doi.org/10.2174/187152008786847701 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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