Abstract
Amphiphilic block copolymers often form core-shell type micelles by self-organization of the blocks in an aqueous medium or under specific experimental conditions. Polymeric micelles constructed from these polymers that contain a segment whose physical or chemical properties respond to small changes in environmental conditions are collectively called ‘stimuli-sensitive ’ micelles. This class of nano-scaled constructs has been investigated as a promising anticancer drug carrier because the micelles are able to utilize small environmental changes and modify drug release kinetics, biodistribution and the interactions with tissues and cells. This review summarizes the recent progress in stimuli-sensitive micelles for tumor chemotherapy, particularly for those responding to hyperthermic conditions, tumor pH and endosomal/ lysosomal pH.
Keywords: Micelles, self-organization, stimuli-sensitive, hyperthermic conditions, tumor pH, endosomal/lysosomal pH
Anti-Cancer Agents in Medicinal Chemistry
Title: Stimuli-Sensitive Polymeric Micelles as Anticancer Drug Carriers
Volume: 6 Issue: 6
Author(s): Kun Na, Vijay T. Sethuraman, You Han Bae and Vijay A. Sethuraman
Affiliation:
Keywords: Micelles, self-organization, stimuli-sensitive, hyperthermic conditions, tumor pH, endosomal/lysosomal pH
Abstract: Amphiphilic block copolymers often form core-shell type micelles by self-organization of the blocks in an aqueous medium or under specific experimental conditions. Polymeric micelles constructed from these polymers that contain a segment whose physical or chemical properties respond to small changes in environmental conditions are collectively called ‘stimuli-sensitive ’ micelles. This class of nano-scaled constructs has been investigated as a promising anticancer drug carrier because the micelles are able to utilize small environmental changes and modify drug release kinetics, biodistribution and the interactions with tissues and cells. This review summarizes the recent progress in stimuli-sensitive micelles for tumor chemotherapy, particularly for those responding to hyperthermic conditions, tumor pH and endosomal/ lysosomal pH.
Export Options
About this article
Cite this article as:
Na Kun, Sethuraman T. Vijay, Han Bae You and Sethuraman A. Vijay, Stimuli-Sensitive Polymeric Micelles as Anticancer Drug Carriers, Anti-Cancer Agents in Medicinal Chemistry 2006; 6 (6) . https://dx.doi.org/10.2174/187152006778699068
DOI https://dx.doi.org/10.2174/187152006778699068 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Novel Synthesis Method of Apogossypolone and its Antitumor Activity
Letters in Drug Design & Discovery Future of Protease Activity Assays
Current Pharmaceutical Design Continuous Nanostructures for the Controlled Release of Drugs
Current Pharmaceutical Design Potential and Perspectives of Cyclonucleosides
Current Medicinal Chemistry Synthesis and Stability Evaluation of New HYNIC Derivatives as Ligands for Technetium-99m
Letters in Organic Chemistry Mycosporine-Like Amino Acids for Skin Photoprotection
Current Medicinal Chemistry Pulmonary Hypertension secondary to Left Heart Disease
Current Vascular Pharmacology Synthesis of Novel 1,4-Substituted 1,2,3-Triazoles by Water-Soluble (Salicyladimine) <sub>2</sub>Cu Complex Catalyzed Azide-Alkyne Cycloaddition in Water
Letters in Organic Chemistry Novel Compounds from Marine Microorganisms that Inhibit Mammalian DNA Polymerase
Current Organic Chemistry Cellular Senescence and Anti-Cancer Therapy
Current Drug Targets MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer
Current Molecular Medicine Pharmacological Management of Type 2 Diabetes Mellitus: An Update
Current Diabetes Reviews Cancer Therapy Based on Smart Drug Delivery with Advanced Nanoparticles
Anti-Cancer Agents in Medicinal Chemistry Lactobacillus rhamnosus GG Influences Polyamine Metabolism in HGC-27 Gastric Cancer Cell Line: A Strategy Toward Nutritional Approach to Chemoprevention of Gastric Cancer
Current Pharmaceutical Design miR-221/222 Confers Radioresistance in Glioblastoma Cells Through Activating Akt Independent of PTEN Status
Current Molecular Medicine An Investigative Approach to Treatment Modalities for Squamous Cell Carcinoma of Skin
Current Drug Delivery Aptamers as Innovative Diagnostic and Therapeutic Agents in the Central Nervous System
CNS & Neurological Disorders - Drug Targets The Effect of Tumour Necrosis Factor-α on Periodontal Ligament Stem Cell Differentiation and the Related Signaling Pathways
Current Stem Cell Research & Therapy bHLH Transcription Factors Inhibitors for Cancer Therapy: General Features for In Silico Drug Design
Current Medicinal Chemistry Potential of Selective Estrogen Receptor Modulators as Treatments and Preventives of Breast Cancer
Anti-Cancer Agents in Medicinal Chemistry