Abstract
Recently, the advancement of nanotechnology has had a significant impact on clinical therapeutics. Advances in biocompatible drug carriers using organic/inorganic nanoparticles have enabled safer and more efficient delivery of anti-cancer agents. In particular, nanoparticles designed and fabricated by sophisticated processes can (as drug carriers) deliver precise doses of multiple anti-cancer agents to target cancer cells, improving therapeutic efficacy and minimizing side effects. In addition, a comprehensive understanding of cancer biology, chemo-resistance, cancer relapse, and metastasis is essential for successful development of combination therapy using nanoparticles. In this review, we discuss the species of functional nanoparticles for delivery of anti-cancer agents and their potential to improve chemotherapeutic indices via combination therapy. We also discuss novel therapeutic strategies using functional nanoparticles developed through multidisciplinary collaboration for combination chemotherapy.
Keywords: Anti-cancer agents, Cancer, Combination chemotherapy, Nanoparticle, Synergistic effect
Anti-Cancer Agents in Medicinal Chemistry
Title:Functional Nanoplatforms for Enhancement of Chemotherapeutic Index
Volume: 13 Issue: 2
Author(s): Jaemoon Yang, Eugene Lee, Minhee Ku, Yong-Min Huh and Jae-Ho Cheong
Affiliation:
Keywords: Anti-cancer agents, Cancer, Combination chemotherapy, Nanoparticle, Synergistic effect
Abstract: Recently, the advancement of nanotechnology has had a significant impact on clinical therapeutics. Advances in biocompatible drug carriers using organic/inorganic nanoparticles have enabled safer and more efficient delivery of anti-cancer agents. In particular, nanoparticles designed and fabricated by sophisticated processes can (as drug carriers) deliver precise doses of multiple anti-cancer agents to target cancer cells, improving therapeutic efficacy and minimizing side effects. In addition, a comprehensive understanding of cancer biology, chemo-resistance, cancer relapse, and metastasis is essential for successful development of combination therapy using nanoparticles. In this review, we discuss the species of functional nanoparticles for delivery of anti-cancer agents and their potential to improve chemotherapeutic indices via combination therapy. We also discuss novel therapeutic strategies using functional nanoparticles developed through multidisciplinary collaboration for combination chemotherapy.
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Cite this article as:
Yang Jaemoon, Lee Eugene, Ku Minhee, Huh Yong-Min and Cheong Jae-Ho, Functional Nanoplatforms for Enhancement of Chemotherapeutic Index, Anti-Cancer Agents in Medicinal Chemistry 2013; 13 (2) . https://dx.doi.org/10.2174/1871520611313020005
DOI https://dx.doi.org/10.2174/1871520611313020005 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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