Generic placeholder image

Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Clinical Importance and Potential Use of Small Molecule Inhibitors of Focal Adhesion Kinase

Author(s): Alexander Schultze and Walter Fiedler

Volume 11, Issue 7, 2011

Page: [593 - 599] Pages: 7

DOI: 10.2174/187152011796817727

Price: $65

Abstract

Since its first description Focal Adhesion Kinase (FAK), a cytoplasmatic tyrosine kinase, has been implicated in the formation and progression of solid and liquid malignant tumors. Therefore orally available selective small molecule inhibitors of FAK have been developed, three of them (PF-562-271, PF-04554878 and GSK2256098) are already in clinical testing. This review discusses the recent data obtained from these Phase 1 trials. We also discuss available data on the mechanisms of action of these inhibitors in carcinogenesis and demonstrate that FAK plays an important role in neoangiogenesis which is a crucial step in cancer growth.

Keywords: Angiogenesis, Chemoresistance, Focal Adhesion Kinase, Metastasis, Migration of tumor cells, Small molecule inhibitors, FAK, neoangiogenesis, PF-04554878, PF-562,271


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy