Abstract
This short perspective briefly covers selected aspects of the past, present and future of antifolates in chemotherapy. Both classical and nonclassical analogs currently in the preclinical stage and clinically used agents are covered.
Keywords: thymidylate synthase (ts), dihydrofolate reductase (dhfr), antifolates, classical, nonclassical, inhibitors
Current Medicinal Chemistry - Anti-Cancer Agents
Title: Antifolates - Past, Present and Future
Volume: 4 Issue: 5
Author(s): Aleem Gangjee and Hiteshkumar D. Jain
Affiliation:
Keywords: thymidylate synthase (ts), dihydrofolate reductase (dhfr), antifolates, classical, nonclassical, inhibitors
Abstract: This short perspective briefly covers selected aspects of the past, present and future of antifolates in chemotherapy. Both classical and nonclassical analogs currently in the preclinical stage and clinically used agents are covered.
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Cite this article as:
Gangjee Aleem and Jain D. Hiteshkumar, Antifolates - Past, Present and Future, Current Medicinal Chemistry - Anti-Cancer Agents 2004; 4 (5) . https://dx.doi.org/10.2174/1568011043352803
DOI https://dx.doi.org/10.2174/1568011043352803 |
Print ISSN 1568-0118 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5968 |
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