Abstract
The abuse of anabolic androgenic steroids (AAS) is relatively widely spread and epidemiological studies in the western countries report a prevalence between 1-5 % among males. The impact of these steroids on the strength and muscle mass as well as many of the adverse physical effects that have been observed are well described. Several reports have also revealed severe psychological effects as results of the administration of AAS. Effects such as irritability, aggressiveness, anxiety and depression are reported to be associated with AAS abuse. The mechanistic rationales behind these effects are not well understood. Several systems are likely to be involved, including the monoamine and peptidergic systems. The aim of this review is to highlight the potential role of the neuropeptide systems in the brain with focus on how these systems are affected by repeated administration of AAS.
Keywords: Anabolic androgenic steroids, nandrolone decanoate, neuropeptide, substance P, opioi, males, strength, muscle mass, adverse physical effects, irritability, aggressiveness, anxiety, depression, peptidergic
Mini-Reviews in Medicinal Chemistry
Title: Impact of Anabolic Androgenic Steroids on Neuropeptide Systems
Volume: 11 Issue: 5
Author(s): M. Hallberg
Affiliation:
Keywords: Anabolic androgenic steroids, nandrolone decanoate, neuropeptide, substance P, opioi, males, strength, muscle mass, adverse physical effects, irritability, aggressiveness, anxiety, depression, peptidergic
Abstract: The abuse of anabolic androgenic steroids (AAS) is relatively widely spread and epidemiological studies in the western countries report a prevalence between 1-5 % among males. The impact of these steroids on the strength and muscle mass as well as many of the adverse physical effects that have been observed are well described. Several reports have also revealed severe psychological effects as results of the administration of AAS. Effects such as irritability, aggressiveness, anxiety and depression are reported to be associated with AAS abuse. The mechanistic rationales behind these effects are not well understood. Several systems are likely to be involved, including the monoamine and peptidergic systems. The aim of this review is to highlight the potential role of the neuropeptide systems in the brain with focus on how these systems are affected by repeated administration of AAS.
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Cite this article as:
Hallberg M., Impact of Anabolic Androgenic Steroids on Neuropeptide Systems, Mini-Reviews in Medicinal Chemistry 2011; 11 (5) . https://dx.doi.org/10.2174/138955711795445961
DOI https://dx.doi.org/10.2174/138955711795445961 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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