Research on Interval-valued Intuitionistic Fuzzy Multi-attribute Decision Making Based on Projection Model

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Author(s): Sha Fu*, Xi-long Qu, Ye-zhi Xiao, Hang-jun Zhou, Yun Zhou.

Journal Name: Recent Advances in Computer Science and Communications
Formerly: Recent Patents on Computer Science

Abstract:

Background: Regarding the multi-attribute decision making where the decision information is the interval-valued intuitionistic fuzzy number and the attribute weight information is not completely determined.

Method: Intuitionistic fuzzy set theory introduces non-membership function, as an extension of the fuzzy set theory, it has certain advantages in solving complex decision making problems. a projection model based interval-valued intuitionistic fuzzy multi-attribute decision making scheme was proposed in this study. The objective weight of the attribute was obtained using improved interval-valued intuitionistic fuzzy entropy, and thus the comprehensive weight of the attribute was obtained according to the preference information.

Results: In the aspect of the decision-making matrix processing, the concept of interval-valued intuitionistic fuzzy ideal point and its related concepts were defined, the score vector of each scheme was calculated, the projection model was constructed to measure the similarity between each scheme and the interval-valued intuitionistic fuzzy ideal point, and the scheme was sorted according to the projection value.

Conclusion: The efficiency and usability of the proposed approach are considered on the case study.

Keywords: Interval-Valued Intuitionistic Fuzzy Number, Multi-Attribute Decision Making, Interval-Valued Intuitionistic Fuzzy Entropy, Score Vector, Projection Model

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DOI: 10.2174/2666255813666191119102344
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Antifungal Proteins from Plant Latex

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Author(s): Mayck Silva Barbosa, Bruna da Silva Souza, Ana Clara Silva Sales, Jhoana D’arc Lopes de Sousa, Francisca Dayane Soares da Silva, Maria Gabriela Araújo Mendes, Káritta Raquel Lustoza da Costa, Taiane Maria de Oliveira, Tatiane Caroline Daboit, Jefferson Soares de Oliveira*.

Journal Name: Current Protein & Peptide Science

Abstract:

Latex, a milky fluid found in several plants, is widely used for many purposes, and its proteins have been investigated. Many studies have shown that latex produced by some plant species is a natural source of biologically active compounds, and many of the hydrolytic enzymes are related to health benefits. Research into the characterization and industrial and pharmaceutical utility of latex has progressed in recent years. Latex proteins are associated with plants’ defense mechanisms, including against attack by fungi. In this respect, there are several biotechnological applications of antifungal proteins. Some findings reveal that antifungal proteins inhibit fungi by interrupting the synthesis of fungal cell walls or rupturing the membrane. Moreover, both phytopathogenic and clinical fungal strains are susceptible to latex proteins. The present review describes some important features of proteins isolated from plant latex which have presented in vitro antifungal activities: protein classification, function, molecular weight, isoelectric point, as well as the fungal species that are inhibited by them. We also discuss their mechanisms of action.

Keywords: Latex, Proteins, Plant, Metabolism, Antifungal agents, Enzymes

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DOI: 10.2174/1389203720666191119101756
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Centre-of-mass-based gait recognition for person identification

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Author(s): Rajib Ghosh*.

Journal Name: Recent Advances in Computer Science and Communications
Formerly: Recent Patents on Computer Science

Abstract:

Background: Gait recognition focuses on identification of persons from their walking activity. This type of system plays an important role in visual surveillance applications. Walking pattern of every person is unique and difficult to replicate by others.

Objective: The present article focuses on to develop a person identification system based on gait recognition.

Methods: In this article, a novel gait recognition approach is proposed to show how human body Centre-of-mass-based walking characteristics can be used to recognize unauthorized and suspicious persons when they enter in a surveillance area. Walking pattern varies from person to person mainly due to the differences in the footsteps and body movement. Initially, background is modelled from the input video captured through static cameras deployed for security purpose. Foreground moving object in the individual frames are then segmented using the background subtraction algorithm. Centre-of-mass based discriminative features of various walking patterns are then studied using Support Vector Machine(SVM) classifier to identify each unique walking pattern.

Results: The proposed system has been evaluated using a self-generated dataset containing side view of various walking video clips. The experimental results demonstrate that the proposed system achieves an encouraging person identification rate.

Conclusion: This work can be further extended to provide a general approach in developing an automatic person identification system in unconstrained environment.

Keywords: Person Identification, Gait Recognition, Centre-Of-Mass, SVM

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DOI: 10.2174/2666255813666191119101348
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Consequences of dicarbonyl stress on skeletal muscle proteins and in Type 2 diabetes

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Author(s): Khurshid Ahmad, Sibhghatulla Shaikh, Eun Ju Lee, Yong-Ho Lee, Inho Choi*.

Journal Name: Current Protein & Peptide Science

Abstract:

Skeletal muscle is the largest organ in the body and constitutes almost 40% of body mass. It is also the primary site of insulin-mediated glucose uptake, and skeletal muscle insulin resistance, that is, diminished response to insulin, is characteristic of Type 2 diabetes (T2DM). One of the foremost reasons posited to explain the etiology of T2DM involves the modification of proteins by dicarbonyl stress due to an unbalanced metabolism and accumulations of dicarbonyl metabolites. The elevated concentration of dicarbonyl metabolites (i.e., glyoxal, methylglyoxal, 3-deoxyglucosone) leads to DNA and protein modifications, causing cell/tissue dysfunctions in several metabolic diseases such as T2DM and other age-associated diseases. In this review, we recapitulate reported effects of dicarbonyl stress on skeletal muscle and associated extracellular proteins with emphasis on the impact of T2DM on skeletal muscle and provide a brief introduction to the prevention/inhibition of dicarbonyl stress.

Keywords: Skeletal muscle, Insulin resistance, Diabetes, Reactive dicarbonyl and glycolytic intermediates, Dicarbonyl stress

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DOI: 10.2174/1389203720666191119100759
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Therapeutic Potential of Medicinal Plant Proteins: Present Status and Future Perspectives

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Author(s): Snober Shabeer Wani, Parvaiz A. Dar, Sajad M. Zargar, Tanveer A. Dar*.

Journal Name: Current Protein & Peptide Science

Abstract:

Biologically active molecules obtained from plant sources, mostly including secondary metabolites, have been considered to be of immense value with respect to treatment of various human diseases. However, some inevitable limitations associated with these secondary metabolites like high cytotoxicity, low bio-availability, poor absorption, low abundance, improper metabolism etc. , have forced the scientific community to explore medicinal plants for alternate biologically active molecules. In this context, therapeutically active proteins/peptides from medicinal plants have been promoted as a promising therapeutic intervention for various human diseases. A large number of proteins isolated from the medicinal plants have been shown to exhibit anti-microbial, anti-oxidant, anti-HIV, anti-cancerous, ribosome inactivating and neuro-modulatory activities. Moreover, with advanced technological developments in the medicinal plant research, medicinal plant proteins such as Bowman-Birk protease inhibitor and Mistletoe Lectin-I are presently under clinical trials against prostrate cancer, oral carcinomas and malignant melanoma. Despite these developments and proteins being potential drug candidates, to date not a single systematic review article has documented the therapeutical potential of the available biologically active medicinal plant proteome. The present artice was therefore designed to describe the current status of the therapeutically active medicinal plant proteins/peptides vis-à-vis their potential as future protein-based drugs for various human diseases. Future insights in this direction have also been highlighted.

Keywords: Protein therapeutics, Antibacterial activity, Antifungal activity, Anticancerous activity, Ribosome inactivating activity, Anti-HIV activitProtein therapeutics, Anti-HIV activity

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DOI: 10.2174/1389203720666191119095624
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Vaccine-Associated Neurological Adverse Events: A Case Report and Literature Review

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Author(s): Maoqiang Tian, Jing Yang, Lei Li, Juan Li, Wenting Lei, Xiaomei Shu*.

Journal Name: Current Pharmaceutical Design

Abstract:

Vaccination is an effective strategy to reduce the burden of preventable illness. However, many clinical reports revealed that various vaccinations may associate with neurological disorders, mainly including autoimmune disease, febrile seizure, and vaccine associated paralytic poliomyelitis (VAPP). Although more and more reports revealed that part of above post-vaccine neurological disorders are not directly related to vaccination, it may be merely coincidence. However, these reports may increase the hesitancy on vaccination for public population and influence the coverage of vaccination. In this report, we described a child with acute flaccid paralysis may be caused by poliovirus vaccine. To provide the feasible ways to realize or reduce the risk of neurological adverse events caused by vaccines, we further provide a mini review of literatures of vaccination associated neurological adverse events. This revealed that oral poliomyelitis vaccine use exclusively and type 2 serotype poliomyelitis vaccine virus were the risk factor of VAPP. Combination vaccine was associated with an increased risk of ADEM and FS following immunization, when compared with administration of vaccines separately. Even though cases have been reported that vaccination may be trigger of anti-NMDARe and GBS, no direct evidences to prove that vaccination increased the risk of GBS and anti-NMDARe.

Keywords: Vaccinations, Neurological Disorders, Febrile Seizure, Vaccine Associated Paralytic Poliomyelitis, Encephalitis, Guillain-Barre Syndrome

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DOI: 10.2174/1381612825666191119095132
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miR-4319 suppresses the growth of esophageal squamous cell carcinoma via targeting NLRC5

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Author(s): Xiao Hu, Min Wang, Lei Cao, Li Cong, Yujie Gao, Jianwei Lu, Jifeng Feng, Bo Shen, Delin Liu*.

Journal Name: Current Molecular Pharmacology

Abstract:

Background: The functions of microRNAs (miRNAs) in cancer progression have been recognized in recent years. However, the role of miR-4319 in esophageal squamous cell carcinoma (ESCC) remains unclear.

Objective: We aimed to investigate the biological roles of miR-4319 in ESCC progression and the associated mechanisms.

Methods: Real-time PCR was performed to examine the levels of miR-4319 in ESCC cell lines. The effects of miR-4319 and NOD-like receptor (NLR) family, caspase activation and recruitment domain (CARD) domain containing 5 (NLRC5) on cell proliferation and cell cycle progression were evaluated using MTT assay, colony formation and flow cytometry assays. Bioinformatics techniques and luciferase reporter assay were applied to validate NLRC5 as a miR-4319 target.

Results: miR-4319 expression was lower in ESCC cells than in normal cell line. Force the expression of miR-4319 repressed cell growth and induced cell cycle arrest. NLRC5 was validated as a direct downstream target of miR-4319. Overexpression of NLRC5 potentiated the effects of miR-4319 on cell growth and cell cycle distribution.

Conclusion: Our results demonstrated that miR-4319 might function as a tumor suppressor by targeting NLRC5 in ESCC.

Keywords: miR-4319, NLRC5, Esophageal squamous cell carcinoma, Cell growthl, Cell cycle

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DOI: 10.2174/1874467212666191119094636
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Advances in the Detection, Mechanism and Therapy of Chronic Kidney Disease

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Author(s): Yu Dong, Xiaosheng Qu, Gang Wu, Xiangdong Luo, Botao Tang, Fangfang Wu, Lanlan Fan, Sooranna Dev, Taisheng Liang*.

Journal Name: Current Pharmaceutical Design

Abstract:

Chronic kidney disease (CKD) is characterized by gradually loss of renal mass and functions. It has become a global health problem with hundreds of millions people affected. Both its incidence and prevalence are increasing over time. More than $20,000 are spent on each patients per year. The economic burden on the patients as well as the society is heavy. And their life quality becomes worsen over time. However, there are still limited effective therapeutic strategies on CKD. Patients mainly rely on dialysis and renal transplantation, which cannot prevent all the complications of CKD. Great efforts are needed in the understanding the nature of CKD progression as well as developing effective therapeutic methods, including pharmacological agents. This paper reviews three aspects in the research of CKD that may show great interests to those who devote in bioanalysis, biomedicine and drug development, including important endogenous biomarkers quantification, mechanisms underlying CKD progression and current status of CKD therapy.

Keywords: Chronic Kidney Disease,Biosensors,Progression Mechanism,Dietary Modification,Gut Microbiota Intervention

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DOI: 10.2174/1381612825666191119094354
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Prenatal stress and maternal immune dysregulation in autism spectrum disorders- potential points for intervention

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Author(s): David Q. Beversdorf*, Hanna E. Stevens, Kara Gross Margolis, Judy Van de Water.

Journal Name: Current Pharmaceutical Design

Abstract:

Background: Genetics are a major etiological contributor to autism spectrum disorder (ASD). Environmental factors, however, also appear to contribute. ASD pathophysiology due to gene x environment is also beginning to be explored. One reason to focus on environmental factors is that they may allow opportunities for intervention or prevention. Methods And Results: Herein, we review two such factors that have been associated with a significant proportion of ASD risk, prenatal stress exposure and maternal immune dysregulation. Maternal stress susceptibility appears to interact with prenatal stress exposure to affect offspring neurodevelopment. We also explore how maternal stress may interact with the microbiome in the neurodevelopmental setting. Additionally, understanding of the impact of maternal immune dysfunction on ASD has recently been advanced by recognition of specific fetal brain proteins targeted by maternal autoantibodies, and identification of unique mid-gestational maternal immune profiles. This might also be interrelated with maternal stress exposure. Animal models have been developed to explore pathophysiology targeting each of these factors. Conclusions: We are beginning to understand the behavioral, pharmacopathological, and epigenetic effects related to these interactions, and we are beginning to explore potential mitigating factors. Continued growth in understanding of these mechanisms may ultimately allow for the identification of multiple potential targets for prevention or intervention for this subset of environmental-associated ASD cases.

Keywords: Autism Spectrum Disorder, Prenatal Stress, Immune Dysregulation, Maternal Antibodies, Microbiome

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DOI: 10.2174/1381612825666191119093335
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Circulating miRNAs in Successful and Unsuccessful Aging. A mini-review

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Author(s): Giuseppe Cammarata, Giovanni Duro*, Tiziana Di Chiara, Alessia Lo Curto, Simona Taverna, Giuseppina Candore.

Journal Name: Current Pharmaceutical Design

Abstract:

Aging is a multifactorial process that affects the organisms at genetic, molecular and cellular level. This process modifies several tissues with a negative impact on cells physiology, tissues and organs functionality, altering their regeneration capacity. The chronic low-grade inflammation typical of aging, defined as inflamm-aging, is a common biological factor responsible for decline and beginning of disease in age. A murine parabiosis model that combines the vascular system of old and young animals, suggests that soluble factors released by young individuals may improve the regenerative potential of old tissue. Therefore, circulating factors have a key role in the induction of aging phenotype. Moreover, lifestyle can influence the physiological status of multiple organs, via epigenetic mechanisms. Recently, microRNAs are considered potential sensors of aging.

Keywords: Circulating Mirnas, Aging, Exosome, Inflammation Mediators, Age-Related Diseases, Mir-21-5p, Mir-126

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DOI: 10.2174/1381612825666191119091644
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