Abstract
Herbal supplements are often used concomitantly with conventional medications resulting in considerable potential for herb-drug interactions. These interactions, which are generally through interfering with pharmacokinetic and/or pharmacodynamic pathways, may result in beneficial effects or more often adverse reactions such as toxicity or treatment failure and may be influenced by multiple environmental and/or genetic factors. The pharmacogenetic approach may help to identify some interactions which may be more pronounced or only occur in specific groups of subjects although the complex nature of the herbal medicines may limit the discovery of such an interaction. Preclinical studies such as gene expression profiling in rodent liver may help to define metabolic pathways influenced by herbal medicines and facilitate more accurate targeting of human in vivo studies. This review discusses the mechanisms of herb-drugs interaction and the potential influence of genetic variation on herb-drug interactions based on available clinical evidence.
Keywords: CYP450, drug transporter, genetic polymorphism, grape fruit juice, herb-drug interaction, pharmacogenetics, St John’s wort, herbal medicines, Herbal supplements, CYP enzymes
Current Pharmaceutical Biotechnology
Title:Herb-Drug Interactions: Methods to Identify Potential Influence of Genetic Variations in Genes Encoding Drug Metabolizing Enzymes and Drug Transporters
Volume: 13 Issue: 9
Author(s): M. Hu, D. Q. Wang, Y. J. Xiao, V. W. L. Mak and B. Tomlinson
Affiliation:
Keywords: CYP450, drug transporter, genetic polymorphism, grape fruit juice, herb-drug interaction, pharmacogenetics, St John’s wort, herbal medicines, Herbal supplements, CYP enzymes
Abstract: Herbal supplements are often used concomitantly with conventional medications resulting in considerable potential for herb-drug interactions. These interactions, which are generally through interfering with pharmacokinetic and/or pharmacodynamic pathways, may result in beneficial effects or more often adverse reactions such as toxicity or treatment failure and may be influenced by multiple environmental and/or genetic factors. The pharmacogenetic approach may help to identify some interactions which may be more pronounced or only occur in specific groups of subjects although the complex nature of the herbal medicines may limit the discovery of such an interaction. Preclinical studies such as gene expression profiling in rodent liver may help to define metabolic pathways influenced by herbal medicines and facilitate more accurate targeting of human in vivo studies. This review discusses the mechanisms of herb-drugs interaction and the potential influence of genetic variation on herb-drug interactions based on available clinical evidence.
Export Options
About this article
Cite this article as:
Hu M., Q. Wang D., J. Xiao Y., W. L. Mak V. and Tomlinson B., Herb-Drug Interactions: Methods to Identify Potential Influence of Genetic Variations in Genes Encoding Drug Metabolizing Enzymes and Drug Transporters, Current Pharmaceutical Biotechnology 2012; 13 (9) . https://dx.doi.org/10.2174/138920112800958805
DOI https://dx.doi.org/10.2174/138920112800958805 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
HIV Integrase Inhibitors: From Diketoacids to Heterocyclic Templates: A History of HIV Integrase Medicinal Chemistry at Merck West Point and Merck Rome (IRBM)
Current Topics in Medicinal Chemistry Restoration of Cardiomyocyte Function in Streptozotocin-Induced Diabetic Rats after Treatment with Vanadate in a Tea Decoction
Current Pharmaceutical Biotechnology The Myometrium in Pregnant Women with Obesity
Current Vascular Pharmacology Preface
Current Cancer Drug Targets Energy Remodeling, Mitochondrial Disorder and Heart Failure
Current Pharmaceutical Design COVID-19: Potential Repurposing Drugs
Infectious Disorders - Drug Targets Micro/Nanoparticle Design and Fabrication for Pharmaceutical Drug Preparation and Delivery Applications
Current Drug Therapy <i>In silico</i> Drug Repurposing for the Identification of Antimalarial Drugs as Candidate Inhibitors of SARS-CoV-2
Anti-Infective Agents Oxidative Stress in the ICU
Current Nutrition & Food Science Clinical Approaches Toward Tumor Angiogenesis: Past, Present and Future
Current Pharmaceutical Design Computer-Based Comparison of Structural Features of Envelope Protein of Alkhurma Hemorrhagic Fever Virus with the Homologous Proteins of Two Closest Viruses
Protein & Peptide Letters Isoform Selective Voltage-Gated Sodium Channel Modulators and the Therapy of Pain
Current Medicinal Chemistry Synthetic and Natural Protease Inhibitors Provide Insights into Parasite Development, Virulence and Pathogenesis
Current Medicinal Chemistry Drug Repurposing: A Strategy for Discovering Inhibitors against Emerging Viral Infections
Current Medicinal Chemistry Antiviral Effects of Asian Natural Products Targeting SARS, MERS, and COVID-19
Coronaviruses Docking and Molecular Dynamics Study on the Inhibitory Activity of Novel Inhibitors on Epidermal Growth Factor Receptor (EGFR)
Medicinal Chemistry Allosteric Enhancers of A1 Adenosine Receptors: State of the Art and New Horizons for Drug Development
Current Medicinal Chemistry Preface
Current Topics in Medicinal Chemistry Molecular Docking and Virtual Screening Based Prediction of Drugs for COVID-19
Combinatorial Chemistry & High Throughput Screening Plasma Gelsolin: Function, Prognostic Value, and Potential Therapeutic Use
Current Protein & Peptide Science