Abstract
Due to the growing toolkit of targeted contrast agents, molecular imaging continues to play a prominent role in the clinical care of cancer. Peptide-based imaging approaches are of particular significance due to their favorable pharmacokinetic properties, established manufacturing infrastructure, and documented clinical success in whole-body imaging. A logical extension of molecular imaging with peptides is to improve surgical outcomes in cancer through highly sensitive and specific probes which can be used intraoperatively. Advances in fluorescent imaging have resulted in various peptide labeling strategies with intraoperative indications. In this review, we focused on the evolving design of peptide imaging agents starting with the clinically used somatostatin targeting peptides. We then review the current synthetic approaches used for dual-labeled agent development and offer perspectives on optimal protection schemes that can be used for multimodal probe development.
Keywords: Dual-labeling, molecular imaging, multimodality, peptides, near-infrared fluorescence, nuclear imaging, cancer, Peptide-based imaging, pharmacokinetic properties, surgical outcomes
Current Medicinal Chemistry
Title:Design of Peptide Imaging Agents for Whole-body and Intraoperative Molecular Imaging
Volume: 19 Issue: 20
Author(s): J. A. Moss, A. L. Vavere and A. Azhdarinia
Affiliation:
Keywords: Dual-labeling, molecular imaging, multimodality, peptides, near-infrared fluorescence, nuclear imaging, cancer, Peptide-based imaging, pharmacokinetic properties, surgical outcomes
Abstract: Due to the growing toolkit of targeted contrast agents, molecular imaging continues to play a prominent role in the clinical care of cancer. Peptide-based imaging approaches are of particular significance due to their favorable pharmacokinetic properties, established manufacturing infrastructure, and documented clinical success in whole-body imaging. A logical extension of molecular imaging with peptides is to improve surgical outcomes in cancer through highly sensitive and specific probes which can be used intraoperatively. Advances in fluorescent imaging have resulted in various peptide labeling strategies with intraoperative indications. In this review, we focused on the evolving design of peptide imaging agents starting with the clinically used somatostatin targeting peptides. We then review the current synthetic approaches used for dual-labeled agent development and offer perspectives on optimal protection schemes that can be used for multimodal probe development.
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Cite this article as:
A. Moss J., L. Vavere A. and Azhdarinia A., Design of Peptide Imaging Agents for Whole-body and Intraoperative Molecular Imaging, Current Medicinal Chemistry 2012; 19 (20) . https://dx.doi.org/10.2174/092986712801215856
DOI https://dx.doi.org/10.2174/092986712801215856 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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