Abstract
Choline is a ubiquitous water soluble nutrient, often associated with the B vitamins; however, not yet officially defined as a B vitamin. It is important in the synthesis of phospholipid components of cell membranes, and plasma lipoproteins, providing structural integrity as well as being important in cell signaling; it is also important in the synthesis of the neurotransmitter acetylcholine, and the oxidized form of choline, glycine betaine, serves as an important methyl donor in the methionine cycle. It is present in a wide variety of foods, and is endogenously synthesized in humans through the sequential methylation of phosphatidylethanolamine. The present article represents an introduction to the nutrition, metabolism, and physiological functions of choline and choline derivatives in humans. The association of choline and choline derivatives in risk of chronic disease, including: neural tube defects, coronary artery disease, cancer, Alzheimer’s disease, dementia, and memory, and cystic fibrosis is reviewed.
Keywords: Choline, choline derivatives, nutrition and metabolism, deficiency and toxicity, chronic disease, methionine cycle, riboflavin, vitamin B6, glycerophosphocholine
Central Nervous System Agents in Medicinal Chemistry
Title:An Introduction to the Nutrition and Metabolism of Choline
Volume: 12 Issue: 2
Author(s): Clarie B. Hollenbeck
Affiliation:
Keywords: Choline, choline derivatives, nutrition and metabolism, deficiency and toxicity, chronic disease, methionine cycle, riboflavin, vitamin B6, glycerophosphocholine
Abstract: Choline is a ubiquitous water soluble nutrient, often associated with the B vitamins; however, not yet officially defined as a B vitamin. It is important in the synthesis of phospholipid components of cell membranes, and plasma lipoproteins, providing structural integrity as well as being important in cell signaling; it is also important in the synthesis of the neurotransmitter acetylcholine, and the oxidized form of choline, glycine betaine, serves as an important methyl donor in the methionine cycle. It is present in a wide variety of foods, and is endogenously synthesized in humans through the sequential methylation of phosphatidylethanolamine. The present article represents an introduction to the nutrition, metabolism, and physiological functions of choline and choline derivatives in humans. The association of choline and choline derivatives in risk of chronic disease, including: neural tube defects, coronary artery disease, cancer, Alzheimer’s disease, dementia, and memory, and cystic fibrosis is reviewed.
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Cite this article as:
B. Hollenbeck Clarie, An Introduction to the Nutrition and Metabolism of Choline, Central Nervous System Agents in Medicinal Chemistry 2012; 12 (2) . https://dx.doi.org/10.2174/187152412800792689
DOI https://dx.doi.org/10.2174/187152412800792689 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
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