Abstract
The importance of Factor Xa and thrombin in thrombosis and haemostasis is widely appreciated in the last years. This understanding logically leads to the concept of Factor Xa and thrombin inhibition as viable and attractive target for the antithrombotic therapy. The following review collects and summarizes information on numerous anticoagulant peptides, proteins, chemical compounds and low molecular weight fragment analogues of natural peptides isolated from hematophagous. Unfortunately, not much data from clinical trials of direct Factor Xa and thrombin inhibitors is available in the present moment. The current information reveals that Factor Xa and thrombin inhibition is a promising approach for prevention and treatment of hemostatic impairments. The synthesis of a low molecular weight synthetic peptide mimetics could be a key point in the fight against many diseases related to haemostatic disorders.
Keywords: Anticoagulant peptides, haemostasis, Factor Xa, thrombin, peptide inhibitors of serine proteinases, blood coagulation cascade.
Mini-Reviews in Medicinal Chemistry
Title:Inhibitors of Serine Proteinases from Blood Coagulation Cascade - View on Current Developments
Volume: 12 Issue: 8
Author(s): D. Danalev
Affiliation:
Keywords: Anticoagulant peptides, haemostasis, Factor Xa, thrombin, peptide inhibitors of serine proteinases, blood coagulation cascade.
Abstract: The importance of Factor Xa and thrombin in thrombosis and haemostasis is widely appreciated in the last years. This understanding logically leads to the concept of Factor Xa and thrombin inhibition as viable and attractive target for the antithrombotic therapy. The following review collects and summarizes information on numerous anticoagulant peptides, proteins, chemical compounds and low molecular weight fragment analogues of natural peptides isolated from hematophagous. Unfortunately, not much data from clinical trials of direct Factor Xa and thrombin inhibitors is available in the present moment. The current information reveals that Factor Xa and thrombin inhibition is a promising approach for prevention and treatment of hemostatic impairments. The synthesis of a low molecular weight synthetic peptide mimetics could be a key point in the fight against many diseases related to haemostatic disorders.
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Danalev D., Inhibitors of Serine Proteinases from Blood Coagulation Cascade - View on Current Developments, Mini-Reviews in Medicinal Chemistry 2012; 12 (8) . https://dx.doi.org/10.2174/138955712801264819
DOI https://dx.doi.org/10.2174/138955712801264819 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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