Generic placeholder image

Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

2,4,6-Trichlorophenylhydrazine Schiff Bases as DPPH Radical and Super Oxide Anion Scavengers

Author(s): Khalid Mohammed Khan, Zarbad Shah, Viqar Uddin Ahmad, Momin Khan, Muhammad Taha, Fazal Rahim, Sajjad Ali, Nida Ambreen, Shahnaz Perveen, M. Iqbal Choudhary and Wolfgang Voelter

Volume 8, Issue 3, 2012

Page: [452 - 461] Pages: 10

DOI: 10.2174/1573406411208030452

Price: $65

Abstract

Syntheses of thirty 2,4,6-trichlorophenylhydrazine Schiff bases 1-30 were carried out and evaluated for their in vitro DPPH radical and super oxide anion scavenging activities. Compounds 1-30 have shown a varying degree of DPPH radical scavenging activity and their IC50 values range between 4.05-369.30 µM. The compounds 17, 28, 18, 14, 8, 15, 12, 2, 29, and 7 exhibited IC50 values ranging between 4.05 ± 0.06-24.42 ± 0.86 µM which are superior to standard n-propylgallate (IC50 = 30.12 ± 0.27 µM). Selected compounds have shown a varying degree of superoxide anion radical scavenger activity and their IC50 values range between 91.23-406.90 µM. The compounds 28 8, 17, 15, and 14, showed IC50 values between 91.23 ± 1.2-105.31 ± 2.29 µM which are superior to standard n-propylgallate (IC50 = 106.34 ± 1.6 µM).

Keywords: 2, 4, 6-Trichlorophenylhydrazine Schiff bases, DPPH radical, superoxide anion scavengers, trichlorophenylhydrazine, radical scavenging, propylgallate, antituberculosis, antifungal, rodenticides


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy