Abstract
A series of mono, bis and mixed Schiff bases (1-7) were synthesised and evaluated for potential anti-glycation and anti-oxidant activities using the bovine serum albumin - glucose assay and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay respectively. All compounds showed significant (p < 0.05) antiglycating activities with IC50 values (4.02 x10-24 ± 0.1 – 2.88 x 10-1 ± 1.35 mM) which were lower than the standard positive control aminoguanidine (IC50 : 1.51 x 10-3 ± 2.11 mM). Moreover, compounds 1-7 were found to possess significant (p < 0.05) DPPH radical scavenging properties with SC50 values (1.31 x 10-19 ± 0.05 to 2.25 x 10-1 ± 1.24 mM) lower than the standard ascorbic acid (SC50 : 5.50 x 10-3 ± 2.11 mM). Compound 6 was found to be the most potent anti-glycating molecule (IC50 value: 4.02 x10-24 ± 0.1 mM) while compound 5 was the most potent anti-oxidant molecule (SC50: 1.31 x 10-19 ± 0.05 mM); both being significantly lower (p < 0.05) than the respective positive controls used. The present data showed that the number of phenolic OH together with structural changes influence both the anti-glycation and anti-oxidant observed herein. This study provides for the first time a series of potential template molecules for possible pharmaceutical applications that warrant further investigation as potential anti-glycation and anti-oxidant agents which could be of importance in metabolic diseases including diabetes mellitus.
Keywords: 2, 3-Diaminopyridine, Schiff bases, Anti-glycation, Anti-oxidant, Hydroxyl analogues, Diabetes mellitus, scavenging, bovine serum albumin
Medicinal Chemistry
Title:In vitro Anti-glycation and Anti-oxidant Properties of Synthesized Schiff Bases
Volume: 8 Issue: 3
Author(s): Sabina Jhaumeer-Laulloo, Minu Gupta Bhowon, Shabneez Mungur, Mohamad Fawzi Mahomoodally and Anwar Hussein Subratty
Affiliation:
Keywords: 2, 3-Diaminopyridine, Schiff bases, Anti-glycation, Anti-oxidant, Hydroxyl analogues, Diabetes mellitus, scavenging, bovine serum albumin
Abstract: A series of mono, bis and mixed Schiff bases (1-7) were synthesised and evaluated for potential anti-glycation and anti-oxidant activities using the bovine serum albumin - glucose assay and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay respectively. All compounds showed significant (p < 0.05) antiglycating activities with IC50 values (4.02 x10-24 ± 0.1 – 2.88 x 10-1 ± 1.35 mM) which were lower than the standard positive control aminoguanidine (IC50 : 1.51 x 10-3 ± 2.11 mM). Moreover, compounds 1-7 were found to possess significant (p < 0.05) DPPH radical scavenging properties with SC50 values (1.31 x 10-19 ± 0.05 to 2.25 x 10-1 ± 1.24 mM) lower than the standard ascorbic acid (SC50 : 5.50 x 10-3 ± 2.11 mM). Compound 6 was found to be the most potent anti-glycating molecule (IC50 value: 4.02 x10-24 ± 0.1 mM) while compound 5 was the most potent anti-oxidant molecule (SC50: 1.31 x 10-19 ± 0.05 mM); both being significantly lower (p < 0.05) than the respective positive controls used. The present data showed that the number of phenolic OH together with structural changes influence both the anti-glycation and anti-oxidant observed herein. This study provides for the first time a series of potential template molecules for possible pharmaceutical applications that warrant further investigation as potential anti-glycation and anti-oxidant agents which could be of importance in metabolic diseases including diabetes mellitus.
Export Options
About this article
Cite this article as:
Jhaumeer-Laulloo Sabina, Gupta Bhowon Minu, Mungur Shabneez, Fawzi Mahomoodally Mohamad and Hussein Subratty Anwar, In vitro Anti-glycation and Anti-oxidant Properties of Synthesized Schiff Bases, Medicinal Chemistry 2012; 8 (3) . https://dx.doi.org/10.2174/1573406411208030409
DOI https://dx.doi.org/10.2174/1573406411208030409 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
Call for Papers in Thematic Issues
Carbohydrates in Computational and Medicinal Chemistry
Carbohydrates are the most essential organic molecules and are involved in the maintenance of various physiological and metabolic processes in living organisms. Carbohydrate-based compounds have come to the attention of researchers because of their significant contributions to biological functions, such as cell development and cell proliferation, connections between several cells, ...read more
Recent Advances in the Medicinal Chemistry of Cancer
Scope of the Thematic Issue: Correlation between structure and function is one of the important aspects of the success of anti-cancer compounds associated with their structure-activity interactions, physiology, biochemical, molecular, and genetic processes. Overcoming these obstacles is key to obtaining further insights into developments in rational drug design, bioorganic chemistry, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Editorial [Hot Topic: Management of Diabetes Mellitus: The Five Pillars of Wisdom (Guest Editors: C.D.A. Stehouwer, N.C. Schaper and M. Huijberts)]
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Small Molecules Activating TrkB Receptor for Treating a Variety of CNS Disorders
CNS & Neurological Disorders - Drug Targets Coexistence of Type-1 Diabetes Mellitus and Papillary Thyroid Carcinoma
Current Diabetes Reviews Host Neuro- Immuno-Endocrine Responses In Periodontal Disease
Current Pharmaceutical Design AMPA Receptor Antagonists: Potential Therapeutic Applications
Recent Patents on CNS Drug Discovery (Discontinued) Therapeutic Targets in Extracellular Protein Deposition Diseases
Current Medicinal Chemistry Renin-Angiotensin System in Central Nervous System Diseases and its Interaction with COVID-19
Current Medicinal Chemistry Therapeutic Effects of Micronutrient Supplements on Sperm Parameters: Fact or Fiction?
Current Pharmaceutical Design “Bridge Proteins” Link Inflammation and Metabolic Diseases: Potential Targets for Therapeutics
Current Protein & Peptide Science Diffusion Tensor Imaging to Determine Effects of Antidementive Treatment on Cerebral Structural Connectivity in Alzheimer’s Disease
Current Pharmaceutical Design The Role of Ketamine in Treatment-Resistant Depression: A Systematic Review
Current Neuropharmacology Physically Cross-linked Hydrogels of β -cyclodextrin Polymer and Poly(ethylene glycol)-cholesterol as Delivery Systems for Macromolecules and Small Drug Molecules
Current Drug Delivery Vascular, Oxidative, and Synaptosomal Abnormalities During Aging and the Progression of Type 2 Diabetes
Current Neurovascular Research A Direct Interaction Between Mitochondrial Proteins and Amyloid-β Peptide and its Significance for the Progression and Treatment of Alzheimer’s Disease
Current Medicinal Chemistry Podocytes as a Target of Insulin
Current Diabetes Reviews Glucose Lowering Activity of Aqueous Ammodaucus leucotrichus Extract in Diabetic Rats
Cardiovascular & Hematological Disorders-Drug Targets May Exercise Prevent Addiction?
Current Neuropharmacology An Update of the Classical and Novel Methods Used for Measuring Fast Neurotransmitters During Normal and Brain Altered Function
Current Neuropharmacology A Commentary on Neuronal Degeneration and Cell Death in Guam ALS and PD: An Evolutionary Process of Understanding
Current Alzheimer Research Application of Resveratrol in Diabetes: Rationale, Strategies and Challenges
Current Molecular Medicine