Abstract
A series of fourteen (14) N-nitrophenyl-N'-(alkyl/aryl)urea and symmetrical 1,3-disubstituted urea derivatives were synthesized and evaluated for their antidepressant activity in mice. Among them, N-(4-nitrophenyl)-N'-(1'-phenylethyl)urea (1), demonstrated profound antidepressant property as reflected by significant reduction in the immobility time (89.83%), whereas compounds 2-6 showed activity values between 36 to 59% which were also larger than the standard phenelzine. Compounds 7-9 were less effective in reducing the immobility period of mice 26.20 to 31.01%). This variable magnitude of antidepressant activity appears to be related to the position of the nitro group to the parent molecules 1, 2, and 8. Compound 1 with the nitro group at para position showed to be the most effective antidepressant. However, the activity declined, if the nitro is attached to ortho and meta positions.
Keywords: Amines, Antidepressant, Disubstituted urea derivatives, Isocyanate, Symmetrical urea, Tail suspension test (TST), carbamates, lipoproteinelevating, cholinergic agents
Medicinal Chemistry
Title:Substituted Urea Derivatives: A Potent Class of Antidepressant Agents
Volume: 8 Issue: 3
Author(s): Shahnaz Perveen, Sana Mustafa, Muhammad A. Khan, Ahsana Dar, Khalid M. Khan and Wolfgang Voelter
Affiliation:
Keywords: Amines, Antidepressant, Disubstituted urea derivatives, Isocyanate, Symmetrical urea, Tail suspension test (TST), carbamates, lipoproteinelevating, cholinergic agents
Abstract: A series of fourteen (14) N-nitrophenyl-N'-(alkyl/aryl)urea and symmetrical 1,3-disubstituted urea derivatives were synthesized and evaluated for their antidepressant activity in mice. Among them, N-(4-nitrophenyl)-N'-(1'-phenylethyl)urea (1), demonstrated profound antidepressant property as reflected by significant reduction in the immobility time (89.83%), whereas compounds 2-6 showed activity values between 36 to 59% which were also larger than the standard phenelzine. Compounds 7-9 were less effective in reducing the immobility period of mice 26.20 to 31.01%). This variable magnitude of antidepressant activity appears to be related to the position of the nitro group to the parent molecules 1, 2, and 8. Compound 1 with the nitro group at para position showed to be the most effective antidepressant. However, the activity declined, if the nitro is attached to ortho and meta positions.
Export Options
About this article
Cite this article as:
Perveen Shahnaz, Mustafa Sana, A. Khan Muhammad, Dar Ahsana, M. Khan Khalid and Voelter Wolfgang, Substituted Urea Derivatives: A Potent Class of Antidepressant Agents, Medicinal Chemistry 2012; 8 (3) . https://dx.doi.org/10.2174/157340612800786615
DOI https://dx.doi.org/10.2174/157340612800786615 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
Call for Papers in Thematic Issues
Carbohydrates in Computational and Medicinal Chemistry
Carbohydrates are the most essential organic molecules and are involved in the maintenance of various physiological and metabolic processes in living organisms. Carbohydrate-based compounds have come to the attention of researchers because of their significant contributions to biological functions, such as cell development and cell proliferation, connections between several cells, ...read more
Recent Advances in the Medicinal Chemistry of Cancer
Scope of the Thematic Issue: Correlation between structure and function is one of the important aspects of the success of anti-cancer compounds associated with their structure-activity interactions, physiology, biochemical, molecular, and genetic processes. Overcoming these obstacles is key to obtaining further insights into developments in rational drug design, bioorganic chemistry, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Effect of Prolonged Anti-HM1: IMSS Entamoeba histolytica Antibody Activity in Humoral and Cellular Immunity of Experimentally Induced Animal Model
Recent Patents on Inflammation & Allergy Drug Discovery ROS Acts as a Double-Edged Sword in the Pathogenesis of Type 2 Diabetes Mellitus: Is Nrf2 a Potential Target for the Treatment?
Mini-Reviews in Medicinal Chemistry Antimicrobial Activity of Oleiyl Glucoside Isolated from the Traditional Medicinal Plant, Capparis decidua
The Natural Products Journal Editorial [Hot Topic: Depression (Part 2) (Guest Editors: Ronald S. Duman and John H. Kehne)]
CNS & Neurological Disorders - Drug Targets Gamma Linolenic Acid: An Antiinflammatory Omega-6 Fatty Acid
Current Pharmaceutical Biotechnology Dysiherbaine: A New Generation of Excitatory Amino Acids of Marine Origin
Central Nervous System Agents in Medicinal Chemistry Onjisaponin B (OB) is Neuroprotective During Cognitive Loss Through Immune-mediated and SIRT1 Pathways
Current Neurovascular Research Effects of Mulberry on The Central Nervous System: A Literature Review
Current Neuropharmacology The Differences in Neural Response to Faces and Non-Faces in the FFA: Evidence from the Central to Peripheral Visual Field
Neuroscience and Biomedical Engineering (Discontinued) Biological and Pharmacological Effects of Gamma-oryzanol: An Updated Review of the Molecular Mechanisms
Current Pharmaceutical Design Role of Hydrogen Sulfide and Polysulfides in Neurological Diseases: Focus on Protein S-Persulfidation
Current Neuropharmacology The Role of MAPK's Signaling in Mediating ApoE4-Driven Pathology In Vivo
Current Alzheimer Research Levosimendan: A Novel Agent in Heart Failure
Recent Patents on Cardiovascular Drug Discovery High Fat Intake, Inflammation and Risk of Neuropsychiatric Disorders
Current Immunology Reviews (Discontinued) Patent Selections
Recent Patents on Drug Delivery & Formulation Plant Secondary Metabolites- Potent Inhibitors of Monoamine Oxidase Isoforms
Central Nervous System Agents in Medicinal Chemistry Sleep and the Immune System
Current Immunology Reviews (Discontinued) Expectancy and the Treatment of Depression: A Review of Experimental Methodology and Effects on Patient Outcome
Current Psychiatry Reviews MAP Segmentation of Time-Frequency Rényi Entropy - Application in Seismic Signals Processing
Recent Patents on Signal Processing (Discontinued) 7-Keto-Δ5-Steroids: Key-Molecules Owning Particular Biological and Chemical Interest
Mini-Reviews in Medicinal Chemistry