Abstract
δ-Carboline and its naturally obtained analogs are of importance due to their wide range of biological properties. In the present review, we intend to discuss the main trends in the synthesis of δ-carboline analogs based on pyridine derivatives (including the Fischer synthesis, Graebe-Ullmann reaction, photochemical cyclization, arylation of substituted pyridines, quinolines, etc.) and indole derivatives in order to compare the potential of finding novel drugs in this series. In other words the development, current status and innovative new options for the design and synthesis of δ-carboline analogs are reviewed here. Published data about the various pharmacological functions and the spectroscopy of compounds belonging to this series are summarized. It also discusses the scope, future perspectives and the problems yet to be explored with respect to the synthesis of functionalised bioactive heteroannulated δ-carbolines in search of novel drugs.
Keywords: delta-Carboline, Cryptolepine, DNA intercalation, Pyrrolo-delta-Carboline, Synthesis
Current Organic Synthesis
Title:Synthetic Strategies for the Construction of δ-Carbolines: A Chemical Ladder in Search of Novel Drugs
Volume: 9 Issue: 3
Author(s): Ankur Gupta, Bhagyashree Kamble, Nanjan Moola Joghee and Chandrasekar Moola Joghee Nanjan
Affiliation:
Keywords: delta-Carboline, Cryptolepine, DNA intercalation, Pyrrolo-delta-Carboline, Synthesis
Abstract: δ-Carboline and its naturally obtained analogs are of importance due to their wide range of biological properties. In the present review, we intend to discuss the main trends in the synthesis of δ-carboline analogs based on pyridine derivatives (including the Fischer synthesis, Graebe-Ullmann reaction, photochemical cyclization, arylation of substituted pyridines, quinolines, etc.) and indole derivatives in order to compare the potential of finding novel drugs in this series. In other words the development, current status and innovative new options for the design and synthesis of δ-carboline analogs are reviewed here. Published data about the various pharmacological functions and the spectroscopy of compounds belonging to this series are summarized. It also discusses the scope, future perspectives and the problems yet to be explored with respect to the synthesis of functionalised bioactive heteroannulated δ-carbolines in search of novel drugs.
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Cite this article as:
Gupta Ankur, Kamble Bhagyashree, Moola Joghee Nanjan and Moola Joghee Nanjan Chandrasekar, Synthetic Strategies for the Construction of δ-Carbolines: A Chemical Ladder in Search of Novel Drugs, Current Organic Synthesis 2012; 9 (3) . https://dx.doi.org/10.2174/157017912801270568
DOI https://dx.doi.org/10.2174/157017912801270568 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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