Pulmonary Defence Mechanisms

Title:Pulmonary Defence Mechanisms

Volume: 8 Issue: 3

Author(s): Thomas S. Wilkinson, Jean-Michel Sallenave and John Simpson

Affiliation:

Keywords: Alveolar macrophages, cellular interplay, clinical applications, cough and sneeze, dendritic cell, host defence, lung epithelial cells, mucociliary apparatus, opsonins, surfactant proteins

Abstract: The lung has evolved an impressive array of strategies to sense and respond to foreign or dangerous material. This review uses an anatomical approach, from nose to alveoli, to detail our current understanding of these pulmonary defence mechanisms at the cellular and molecular level. Recent advances since the beginning of the 21st century have been given particular focus. The review initially focuses on individual host defence mechanisms of the upper airways including; the nose, sneeze, cough, the mucociliary apparatus, epithelial cells and dentritic cell network. Then we discuss individual mechanisms of the lower airways including the contribution of macrophages and opsonins to host defence. We then focus attention on the cellular interplay between the mechanisms discussed before finally presenting experimental and clinical evidence of advances that are based on our greater understanding of pulmonary defence mechanisms.

Cite this article as:

S. Wilkinson Thomas, Sallenave Jean-Michel and Simpson John, Pulmonary Defence Mechanisms, Current Respiratory Medicine Reviews 2012; 8 (3) . https://dx.doi.org/10.2174/157339812800493322