Abstract
Adrenergic receptor signaling and heart failure are inextricably linked. Beta-adrenergic receptors (β-ARs) serve not only as physiological modulators of heart rate and contractility, they are also primary therapeutic targets of individuals with heart failure as well as many other cardiovascular disorders. In light of these relationships, this short review will focus on the basic pharmacology distinguishing adrenergic receptor subtypes; on receptor subtype selective signaling; the molecular basis of β-AR gene expression; and, delve briefly into genetic variation of β-ARs that represents a potential basis of differential natural history of heart failure progression and that may serve as an underlying basis for therapeutic response.
Keywords: Adrenergic receptors, signaling, gene regulation, genetic variation, heart failure
Current Signal Transduction Therapy
Title:Beta-adrenergic Signaling: Complexities and Therapeutic Relevance to Heart Failure
Volume: 7 Issue: 2
Author(s): J. David Port
Affiliation:
Keywords: Adrenergic receptors, signaling, gene regulation, genetic variation, heart failure
Abstract: Adrenergic receptor signaling and heart failure are inextricably linked. Beta-adrenergic receptors (β-ARs) serve not only as physiological modulators of heart rate and contractility, they are also primary therapeutic targets of individuals with heart failure as well as many other cardiovascular disorders. In light of these relationships, this short review will focus on the basic pharmacology distinguishing adrenergic receptor subtypes; on receptor subtype selective signaling; the molecular basis of β-AR gene expression; and, delve briefly into genetic variation of β-ARs that represents a potential basis of differential natural history of heart failure progression and that may serve as an underlying basis for therapeutic response.
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Cite this article as:
David Port J., Beta-adrenergic Signaling: Complexities and Therapeutic Relevance to Heart Failure, Current Signal Transduction Therapy 2012; 7 (2) . https://dx.doi.org/10.2174/157436212800376645
DOI https://dx.doi.org/10.2174/157436212800376645 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
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