Abstract
Here we provide background information for the pathobiological concept of a “sick lung circulation”, and how it may affect cardiac function. We propose that in most chronic and progressive lung diseases, but in particular COPD/emphysema and interstitial lung diseases (ILD), there are significant pathological changes of the small pulmonary vessels. Complementing the WHO classification of pulmonary vascular diseases we provide a classification which is based on pathogenetic mechanisms such as inflammation, hypoxia and angioproliferation. We also propose that chronic lung disease – related ‘cor pulmonale’ is insufficiently explained by an elevation of the pulmonary arterial pressure.
Keywords: COPD, emphysema, lung vascular remodeling, HIF-1 &agr;, VEGF, endothelial-mesenchyma transition [EnMT], “sick lung circulation”
Current Respiratory Medicine Reviews
Title:Pulmonary Hypertension and Right Ventricular Dysfunction in Chronic Lung Diseases: New Pathobiologic Concepts
Volume: 8 Issue: 2
Author(s): Jose Gomez-Arroyo, Herman J. Bogaard, Laszlo Farkas, Antonio Abbate, Norbert F. Voelkel
Affiliation:
Keywords: COPD, emphysema, lung vascular remodeling, HIF-1 &agr;, VEGF, endothelial-mesenchyma transition [EnMT], “sick lung circulation”
Abstract: Here we provide background information for the pathobiological concept of a “sick lung circulation”, and how it may affect cardiac function. We propose that in most chronic and progressive lung diseases, but in particular COPD/emphysema and interstitial lung diseases (ILD), there are significant pathological changes of the small pulmonary vessels. Complementing the WHO classification of pulmonary vascular diseases we provide a classification which is based on pathogenetic mechanisms such as inflammation, hypoxia and angioproliferation. We also propose that chronic lung disease – related ‘cor pulmonale’ is insufficiently explained by an elevation of the pulmonary arterial pressure.
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Cite this article as:
Jose Gomez-Arroyo, Herman J. Bogaard, Laszlo Farkas, Antonio Abbate, Norbert F. Voelkel , Pulmonary Hypertension and Right Ventricular Dysfunction in Chronic Lung Diseases: New Pathobiologic Concepts, Current Respiratory Medicine Reviews 2012; 8 (2) . https://dx.doi.org/10.2174/157339812799859798
DOI https://dx.doi.org/10.2174/157339812799859798 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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