Abstract
This review summarizes recent research on biomarkers of tissue remodeling in different body fluids of patients suffering with pulmonary diseases. In particular we focus on elastin breakdown products, matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in syndromes such as chronic obstructive pulmonary disease, pulmonary hypertension, acute lung injury/acute respiratory distress syndrome and cystic fibrosis. Data from both preclinical disease models as well as clinical evaluation of the aforementioned biomarkers will be examined.
Keywords: Biomarker, pulmonary disease, desmosine, matrix metalloproteinase-2, -9, -12, tissue inhibitor of matrix metalloproteinase-4
Current Respiratory Medicine Reviews
Title:Biomarkers of Lung Tissue Remodeling in Pulmonary Diseases: Implications for Clinical Practice and Research
Volume: 8 Issue: 2
Author(s): Frank Kramer, Alex Dusek
Affiliation:
Keywords: Biomarker, pulmonary disease, desmosine, matrix metalloproteinase-2, -9, -12, tissue inhibitor of matrix metalloproteinase-4
Abstract: This review summarizes recent research on biomarkers of tissue remodeling in different body fluids of patients suffering with pulmonary diseases. In particular we focus on elastin breakdown products, matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in syndromes such as chronic obstructive pulmonary disease, pulmonary hypertension, acute lung injury/acute respiratory distress syndrome and cystic fibrosis. Data from both preclinical disease models as well as clinical evaluation of the aforementioned biomarkers will be examined.
Export Options
About this article
Cite this article as:
Frank Kramer, Alex Dusek , Biomarkers of Lung Tissue Remodeling in Pulmonary Diseases: Implications for Clinical Practice and Research, Current Respiratory Medicine Reviews 2012; 8 (2) . https://dx.doi.org/10.2174/157339812799859770
DOI https://dx.doi.org/10.2174/157339812799859770 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pharmacological and Lifestyle Factors Modulating Serum Paraoxonase-1 Activity
Mini-Reviews in Medicinal Chemistry Hypertension in Peripheral Arterial Disease
Current Pharmaceutical Design The Role of Combined Assessment of Defense Against Oxidative Stress and Inflammation in the Evaluation of Peripheral Arterial Disease
Current Molecular Medicine Patterns of Self-Medication with Medicinal Plants and Related Adverse Events - A South American Survey
Current Drug Safety Analytical Methods for the Determination of Sartans in Pharmaceutical Formulations and Biological Fluids: A Review
Current Analytical Chemistry Understanding the Multifaceted Role of Inflammatory Mediators in Ischemic Stroke
Current Medicinal Chemistry New Developments In Treatment After Lung Transplantation
Current Pharmaceutical Design New Steroidal Anti-Inflammatory Antedrugs: 21-Thioalkylether Derivatives of Methyl 16-Prednisolone Carboxylates
Medicinal Chemistry Endocannabinoid Receptor Antagonists and Other Emerging Pharmacological Strategies for Weight Reduction
Current Drug Targets - Cardiovascular & Hematological Disorders Meet Our Editorial Board Member
Current Clinical Pharmacology Preventive Role of Resveratrol Against Inflammatory Cytokines and Related Diseases
Current Pharmaceutical Design Novelty in Treatment of Pulmonary Fibrosis: Pulmonary Hypertension Drugs and Others
Cardiovascular & Hematological Agents in Medicinal Chemistry Overlaps in the Nosology of Substance Abuse and Overeating: The Translational Implications of “Food Addiction”
Current Drug Abuse Reviews Anti-Vascular Endothelial Growth Factor (VEGF) Therapy: A New Cause of Hypertension
Current Hypertension Reviews Smooth Muscle Cell Pathophysiology and Advanced Glycation End Products (AGEs)
Current Drug Targets Development and Validation of a Sensitive HPLC-MS/MS-ESI Method for Determination of Febuxostat: Application to Pharmacokinetic Study
Current Analytical Chemistry Cell Cycle Dependent Regulation of Intracellular Calcium Concentration in Vascular Smooth Muscle Cells: A Potential Target for Drug Therapy
Current Drug Targets - Cardiovascular & Hematological Disorders Heat Shock Proteins - Two Sides of a Coin
Current Cardiology Reviews Recent Applications of Triazolopyrimidine-Based Bioactive Compounds in Medicinal and Agrochemical Chemistry
Mini-Reviews in Medicinal Chemistry Synthesis and Biological Interest of Structured Docosahexaenoic Acid–Containing Triacylglycerols and Phospholipids
Current Organic Chemistry