Abstract
The literature data confirm that membrane rafts are required for the proper organization of signalling pathway within lung parenchyma. The physiological role of membrane rafts appears to be closely linked to their ability to modulate contraction, cell proliferation, matrix protein and mediator production by airway mesenchymal and airway/alveolar epithelial cells.
In particular, the data obtained in endothelial cells suggest that in membrane rafts signalling complexes are assembled allowing a rapid, efficient and regulated response to extracellular stimuli. In fact, the presence of caveolae and Cav-1 is required in endothelial cells for short and long term mechano-transduction in blood vessels. The endothelium lacking caveolae is unable to couple changes in blood flow with proportional vascular remodeling, suggesting that caveolae might represent an initial flow mechano-sensor directly regulated by luminal blood flow. It is evident that membrane rafts, particularly caveolae, play critical roles in several cell types present in the lung and the aberrant regulation of caveolin expression may trigger pulmonary defects, including pulmonary hypertension, inflammation and fibros
A better understanding of dynamics of caveolae in transmembrane traffic in the lung might be of specific interest in drug targeting delivery.
Keywords: Caveolae, lipid rafts, pulmonary hypertension, edema, fibrosis and inflammation
Current Respiratory Medicine Reviews
Title:Membrane Rafts in the Respiratory System
Volume: 8 Issue: 2
Author(s): Paola Palestini, Diana Cunati, Francesca Farina, Laura Botto
Affiliation:
Keywords: Caveolae, lipid rafts, pulmonary hypertension, edema, fibrosis and inflammation
Abstract: The literature data confirm that membrane rafts are required for the proper organization of signalling pathway within lung parenchyma. The physiological role of membrane rafts appears to be closely linked to their ability to modulate contraction, cell proliferation, matrix protein and mediator production by airway mesenchymal and airway/alveolar epithelial cells.
In particular, the data obtained in endothelial cells suggest that in membrane rafts signalling complexes are assembled allowing a rapid, efficient and regulated response to extracellular stimuli. In fact, the presence of caveolae and Cav-1 is required in endothelial cells for short and long term mechano-transduction in blood vessels. The endothelium lacking caveolae is unable to couple changes in blood flow with proportional vascular remodeling, suggesting that caveolae might represent an initial flow mechano-sensor directly regulated by luminal blood flow. It is evident that membrane rafts, particularly caveolae, play critical roles in several cell types present in the lung and the aberrant regulation of caveolin expression may trigger pulmonary defects, including pulmonary hypertension, inflammation and fibros
A better understanding of dynamics of caveolae in transmembrane traffic in the lung might be of specific interest in drug targeting delivery.
Export Options
About this article
Cite this article as:
Paola Palestini, Diana Cunati, Francesca Farina, Laura Botto , Membrane Rafts in the Respiratory System, Current Respiratory Medicine Reviews 2012; 8 (2) . https://dx.doi.org/10.2174/157339812799859815
DOI https://dx.doi.org/10.2174/157339812799859815 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Structure and Function of Myelinated Nerve Fibers in the Rabbit Eye Following Ischemia/Reperfusion Injury
Current Neurovascular Research Editorial from Editor-in-Chief: Are Implanted Upper Airway Stimulation Devices for the Treatment of Obstructive Sleep Apnea Ready for Primetime?
Current Respiratory Medicine Reviews Effect of Soy Isoflavone Supplementation on Endothelial Dysfunction and Oxidative Stress in Equol-Producing Postmenopausal Women
Endocrine, Metabolic & Immune Disorders - Drug Targets Thrombophilia in Pregnancy: Maternal and Fetal Implications
Current Women`s Health Reviews Adenosine A<sub>2A</sub> Receptor Antagonists as Positron Emission Tomography (PET) Tracers
Current Medicinal Chemistry Mechanisms of Salt-Sensitive Hypertension
Current Hypertension Reviews Gender Differences in Metabolic Syndrome – A Key Research Issue
Endocrine, Metabolic & Immune Disorders - Drug Targets Pharmacological Therapy in Children with Atrioventricular Reentry: Which Drug?
Current Pharmaceutical Design Life-Threatening Respiratory Syncytial Virus Disease in Children
Current Respiratory Medicine Reviews Educating Scientists in Translational and Entrepreneurial Medicine: Unmet Needs and Challenges
Technology Transfer and Entrepreneurship (Discontinued) Graphical Abstracts:
Current Nutrition & Food Science Endothelin Receptor Antagonists: A New Therapeutic Option for Improving the Outcome after Solid Organ Transplantation?
Current Vascular Pharmacology Pharmacogenetics Strategies: From Candidate Genes to Whole-Genome Association Analysis. Exploratory or Confirmatory Studies?
Current Pharmacogenomics and Personalized Medicine Preface [Hot topic: Modern Aspects in the Design And Discovery of Novel Antihypertensive Drugs (Guest Editor: Thomas Mavromoustakos)]
Current Topics in Medicinal Chemistry Therapeutic Potential of Targeting Protease Activated Receptors in Cardiovascular Diseases
Current Pharmaceutical Design Effects of PPARγ Agonists against Vascular and Renal Dysfunction
Current Molecular Pharmacology Design and Development of Novel Azo Prodrugs using Various Permutations and Combinations of 5- and 4-Aminosalicylic Acids for Inflammatory Bowel Disease: A Colon-Targeted Approach
Inflammation & Allergy - Drug Targets (Discontinued) Lisinopril-loaded Chitosan Nanoparticles and Indapamide in Hard Gelatine Capsules: Simultaneous HPLC Quantification
Current Pharmaceutical Analysis Membrane Bound Members of the M1 Family: More Than Aminopeptidases
Protein & Peptide Letters The Essential Role of Primary Caregiver in Early Detection of Familial Hypercholesterolemia and Cardiovascular Prevention
Current Pediatric Reviews