Abstract
Proprotein Convertase Subtilisin Kexin9 (PCSK9), originally called Neural Apoptosis-Regulated Convertase1 (NARC1), is the latest member of mammalian subtilase super-family. Since its discovery in 2003, it has drawn significant attention because of its function in the degradation of Low Density Lipoprotein Receptor (LDL-R). LDL-R removes circulating LDL-cholesterol (LDL-C) in the blood. Increased level of PCSK9 functional activity will lead to an accumulation of cholesterol in the blood - a high risk factor for cardiovascular disease. This is confirmed by PCSK9 knock out and transgenic animals, various biochemical and clinical studies involving “gain and loss of function” genetic mutations of PCSK9 found in various subset of populations. Owing to this finding, development of strategies for inhibition of PCSK9 function has drawn significant research interest for therapeutic intervention of hypercholesterolemia. Thus PCSK9 is a target for the development of new cholesterol lowering drugs.
Keywords: Proprotein convertase subtilisin Kexin9 (PCSK9), low density lipoprotein receptor, low density lipoproteincholesterol, hypercholesterolemia, cholesterol lowering agents, PCSK9 inhibitors, Hypercholesterolemia (ADH), trans Golgi network (TGN), lysosome compartments, fluorogenic peptide
Protein & Peptide Letters
Title:Proprotein Convertase Subtilisin Kexin9 (PCSK9): A Novel Target For Cholesterol Regulation
Volume: 19 Issue: 6
Author(s): Ajoy Basak, Heather Palmer-Smith and Priyambada Mishra
Affiliation:
Keywords: Proprotein convertase subtilisin Kexin9 (PCSK9), low density lipoprotein receptor, low density lipoproteincholesterol, hypercholesterolemia, cholesterol lowering agents, PCSK9 inhibitors, Hypercholesterolemia (ADH), trans Golgi network (TGN), lysosome compartments, fluorogenic peptide
Abstract: Proprotein Convertase Subtilisin Kexin9 (PCSK9), originally called Neural Apoptosis-Regulated Convertase1 (NARC1), is the latest member of mammalian subtilase super-family. Since its discovery in 2003, it has drawn significant attention because of its function in the degradation of Low Density Lipoprotein Receptor (LDL-R). LDL-R removes circulating LDL-cholesterol (LDL-C) in the blood. Increased level of PCSK9 functional activity will lead to an accumulation of cholesterol in the blood - a high risk factor for cardiovascular disease. This is confirmed by PCSK9 knock out and transgenic animals, various biochemical and clinical studies involving “gain and loss of function” genetic mutations of PCSK9 found in various subset of populations. Owing to this finding, development of strategies for inhibition of PCSK9 function has drawn significant research interest for therapeutic intervention of hypercholesterolemia. Thus PCSK9 is a target for the development of new cholesterol lowering drugs.
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Cite this article as:
Basak Ajoy, Palmer-Smith Heather and Mishra Priyambada, Proprotein Convertase Subtilisin Kexin9 (PCSK9): A Novel Target For Cholesterol Regulation, Protein & Peptide Letters 2012; 19 (6) . https://dx.doi.org/10.2174/092986612800494020
DOI https://dx.doi.org/10.2174/092986612800494020 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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