Abstract
Matrix metalloproteinases (MMPs) are a family of zinc metallo-endopeptidases secreted by cells and are responsible for much of the turnover of matrix components. Several studies have shown that MMPs are involved in all stages of the atherosclerotic process, from the initial lesion to plaque rupture. Recent evidence suggests thatMMP activity may facilitate atherosclerosis, plaque destabilization, and platelet aggregation. In the heart, matrix metalloproteinases participate in vascular remodeling, plaque instability, and ventricular remodelling after cardiac injury. The aim of the present article is to review the structure, function, regulation of MMPs and to discuss their potential role in the pathogenesis of acute coronary syndromes, as well as their contribution and usefullness in the setting of the disease.
Keywords: Current Perspectives, Acute coronary syndromes, atherosclerosis, inflammation, matrix metalloproteinases, myocardial infarction, zinc metallo-endopeptidases, plaque formation, atherosclerotic process, initial lesion, plaque rupture, vascular remodeling, cardiac injury, acute coronary syndromes, endothelial dysfunction
Current Topics in Medicinal Chemistry
Title:Matrix Metalloproteinases in Acute Coronary Syndromes: Current Perspectives
Volume: 12 Issue: 10
Author(s): Anna-Maria Kampoli, Dimitris Tousoulis, Nikolaos Papageorgiou, Charalambos Antoniades, Emmanuel Androulakis, Eleftherios Tsiamis, George Latsios and Christodoulos Stefanadis
Affiliation:
Keywords: Current Perspectives, Acute coronary syndromes, atherosclerosis, inflammation, matrix metalloproteinases, myocardial infarction, zinc metallo-endopeptidases, plaque formation, atherosclerotic process, initial lesion, plaque rupture, vascular remodeling, cardiac injury, acute coronary syndromes, endothelial dysfunction
Abstract: Matrix metalloproteinases (MMPs) are a family of zinc metallo-endopeptidases secreted by cells and are responsible for much of the turnover of matrix components. Several studies have shown that MMPs are involved in all stages of the atherosclerotic process, from the initial lesion to plaque rupture. Recent evidence suggests thatMMP activity may facilitate atherosclerosis, plaque destabilization, and platelet aggregation. In the heart, matrix metalloproteinases participate in vascular remodeling, plaque instability, and ventricular remodelling after cardiac injury. The aim of the present article is to review the structure, function, regulation of MMPs and to discuss their potential role in the pathogenesis of acute coronary syndromes, as well as their contribution and usefullness in the setting of the disease.
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Kampoli Anna-Maria, Tousoulis Dimitris, Papageorgiou Nikolaos, Antoniades Charalambos, Androulakis Emmanuel, Tsiamis Eleftherios, Latsios George and Stefanadis Christodoulos, Matrix Metalloproteinases in Acute Coronary Syndromes: Current Perspectives, Current Topics in Medicinal Chemistry 2012; 12 (10) . https://dx.doi.org/10.2174/1568026611208011192
DOI https://dx.doi.org/10.2174/1568026611208011192 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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