Abstract
The use of current antiepileptic drugs has been questioned due to the nonselectivity of the drugs and the undesirable side effects posed by them. This led to an intensive investigation in this area worldwide during the past 10 years. There have been some significant outcomes and the findings are promising as far as drug efficacy and safety is concerned. This review covers the new anticonvulsant agents that have shown encouraging activities and less neurotoxicity. A detailed pharmacology and pathophysiology of different types of epilepsy is described here with the structural classification of most active agents. The new structural classes of compounds may prove as lead molecules and good candidates for the future investigations.
Keywords: Epilepsy, seizures, GABA, anticonvulsants, semicarbazones, benzodiazepines, barbiturates, quinazolines
Current Topics in Medicinal Chemistry
Title:An Insight into the New Anticonvulsant Agents
Volume: 12 Issue: 9
Author(s): Waquar Ahsan, Mohsin M. Safhi, Nadeem Siddiqui, Shamama Javed, M. Shamsher Alam, Bishmillah Azad and Jawaid Akhtar
Affiliation:
Keywords: Epilepsy, seizures, GABA, anticonvulsants, semicarbazones, benzodiazepines, barbiturates, quinazolines
Abstract: The use of current antiepileptic drugs has been questioned due to the nonselectivity of the drugs and the undesirable side effects posed by them. This led to an intensive investigation in this area worldwide during the past 10 years. There have been some significant outcomes and the findings are promising as far as drug efficacy and safety is concerned. This review covers the new anticonvulsant agents that have shown encouraging activities and less neurotoxicity. A detailed pharmacology and pathophysiology of different types of epilepsy is described here with the structural classification of most active agents. The new structural classes of compounds may prove as lead molecules and good candidates for the future investigations.
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Ahsan Waquar, M. Safhi Mohsin, Siddiqui Nadeem, Javed Shamama, Shamsher Alam M., Azad Bishmillah and Akhtar Jawaid, An Insight into the New Anticonvulsant Agents, Current Topics in Medicinal Chemistry 2012; 12 (9) . https://dx.doi.org/10.2174/156802612800229233
DOI https://dx.doi.org/10.2174/156802612800229233 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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