Abstract
Macrocyclic lactones (MLs), exemplified by the prototype of the class, ivermectin (IVM), are mainstays of programs for the control of nematode and arthropod parasites and pests. Since their introduction 30 years ago, research has revealed that they act on a family of ligand-gated chloride channels gated by glutamate, which is largely restricted to animals in the phyla Nematoda and Arthropoda. Studies on IVM in model organisms have contributed greatly to our understanding of ML pharmacology, but our understanding of the basis for differences among species and among MLs in potency and spectrum remains far from complete.
Keywords: Nematode, parasite, arthropod, glutamate-gated chloride channel, ivermectin
Current Pharmaceutical Biotechnology
Title:Macrocyclic Lactone Anthelmintics: Spectrum of Activity and Mechanism of Action
Volume: 13 Issue: 6
Author(s): Timothy G. Geary and Yovany Moreno
Affiliation:
Keywords: Nematode, parasite, arthropod, glutamate-gated chloride channel, ivermectin
Abstract: Macrocyclic lactones (MLs), exemplified by the prototype of the class, ivermectin (IVM), are mainstays of programs for the control of nematode and arthropod parasites and pests. Since their introduction 30 years ago, research has revealed that they act on a family of ligand-gated chloride channels gated by glutamate, which is largely restricted to animals in the phyla Nematoda and Arthropoda. Studies on IVM in model organisms have contributed greatly to our understanding of ML pharmacology, but our understanding of the basis for differences among species and among MLs in potency and spectrum remains far from complete.
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Cite this article as:
G. Geary Timothy and Moreno Yovany, Macrocyclic Lactone Anthelmintics: Spectrum of Activity and Mechanism of Action, Current Pharmaceutical Biotechnology 2012; 13 (6) . https://dx.doi.org/10.2174/138920112800399077
DOI https://dx.doi.org/10.2174/138920112800399077 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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