Abstract
Cinnamic acid and its phenolic analogues are natural substances. Chemically, cinnamic acids or the 3-phenyl acrylic acids, offer three main reactive sites: substitution on the phenyl ring, addition on the α ,β -unsaturation and reactions of the carboxylic acid. Owing to these chemical aspects, cinnamic acid derivatives received much attention in medicinal research as traditional as well as valuable scaffolds in recent synthetic bioactive agents. In the last two decades, there has been huge attention towards various cinnamoyl derivatives and their biological efficacy. This review provides a comprehensive literature compilation concerning the synthesis of various cinnamoyl acids, esters, amides, hydrazides and related derivatives and their biological activity evaluations against diseases such as tuberculosis and malaria, which are frequent in developing countries and cardiovascular diseases, which cause a high mortality rate worldwide. We envisage that our effort in this review contributes a much needed and timely addition to the literature of medicinal research.
Keywords: Antituberculosis, Antimalarial agents, Cardiovascular diseases, Cinnamic acid, Cinnamide, Cinnamoyl ester, Cinnamic hydrazide, Cinnamic Ester Derivatives, rhamnose moiety, anti-tuberculosis assay, leptophyllin B, bioactive styryllactones, alkaloids, howiinin A, cinnamoyl ester moiety
Current Organic Chemistry
Title:Cinnamic Acid Derivatives in Tuberculosis, Malaria and Cardiovascular Diseases - A Review
Volume: 16 Issue: 6
Author(s): Prithwiraj De, Florence Bedos-Belval, Corinne Vanucci-Bacque, Michel Baltas
Affiliation:
Keywords: Antituberculosis, Antimalarial agents, Cardiovascular diseases, Cinnamic acid, Cinnamide, Cinnamoyl ester, Cinnamic hydrazide, Cinnamic Ester Derivatives, rhamnose moiety, anti-tuberculosis assay, leptophyllin B, bioactive styryllactones, alkaloids, howiinin A, cinnamoyl ester moiety
Abstract:
Cinnamic acid and its phenolic analogues are natural substances. Chemically, cinnamic acids or the 3-phenyl acrylic acids, offer three main reactive sites: substitution on the phenyl ring, addition on the α ,β -unsaturation and reactions of the carboxylic acid. Owing to these chemical aspects, cinnamic acid derivatives received much attention in medicinal research as traditional as well as valuable scaffolds in recent synthetic bioactive agents. In the last two decades, there has been huge attention towards various cinnamoyl derivatives and their biological efficacy. This review provides a comprehensive literature compilation concerning the synthesis of various cinnamoyl acids, esters, amides, hydrazides and related derivatives and their biological activity evaluations against diseases such as tuberculosis and malaria, which are frequent in developing countries and cardiovascular diseases, which cause a high mortality rate worldwide. We envisage that our effort in this review contributes a much needed and timely addition to the literature of medicinal research.
Export Options
About this article
Cite this article as:
Prithwiraj De, Florence Bedos-Belval, Corinne Vanucci-Bacque, Michel Baltas , Cinnamic Acid Derivatives in Tuberculosis, Malaria and Cardiovascular Diseases - A Review, Current Organic Chemistry 2012; 16 (6) . https://dx.doi.org/10.2174/138527212799958020
DOI https://dx.doi.org/10.2174/138527212799958020 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Plasma Steroid Level Measured Using Modern Separation Techniques as Biomarkers in Biological Diagnostics
Current Pharmaceutical Analysis Peripheral Arterial Disease - The Forgotten Risk Factor
Vascular Disease Prevention (Discontinued) Preface (Hot Topic: Medicinal Strategies in the Treatment of Obesity Guest Editor: Akio Inui)
Current Medicinal Chemistry - Central Nervous System Agents The role of interleukin 35 in atherosclerosis
Current Pharmaceutical Design Evaluation of Left Ventricular Volumes and Ejection Fraction from Gated Myocardial Perfusion SPECT Processed with “Myovation Evolution”: Comparison of Three Automated Software Packages using Cardiac Magnetic Resonance as Reference
Current Radiopharmaceuticals Gene Expression Profiling Analysis to Identify Key Genes and Underlying Mechanisms in Meniscus of Osteoarthritis Patients
Combinatorial Chemistry & High Throughput Screening Osteoprotegerin and Diabetes-Associated Pathologies
Current Molecular Medicine Daily Melatonin Administration Attenuates Age-Dependent Disturbances of Cardiovascular Rhythms
Current Aging Science Mitochondrial Targeting for Development of Novel Drug Strategies in Brain Injury
Central Nervous System Agents in Medicinal Chemistry Cardiovascular-Related
Current Bioactive Compounds COVID-19: Our Current Knowledge of Epidemiology, Pathology, Therapeutic Approaches, and Diagnostic Methods
Anti-Cancer Agents in Medicinal Chemistry Meet Our Associate Editor
Current Cardiology Reviews Macrophages in Immunopathology of Atherosclerosis: A Target for Diagnostics and Therapy
Current Pharmaceutical Design Endogenous Cardioprotective Agents: Role in Pre and Postconditioning
Current Drug Targets Potentiating the Naturally Occurring Process for Repair of Damaged Heart
Current Pharmaceutical Design Antimutagenic Activity of Lutein –An Oxycarotenoid Present in the Macula and its Inhibition of Cytochrome P 450 Enzymes in vitro
Drug Metabolism Letters Piribedil: Antiparkinsonian Properties and Potential Clinical Utility in Dopaminergic Disorders
Current Drug Therapy Oleacein. Translation from Mediterranean Diet to Potential Antiatherosclerotic Drug
Current Pharmaceutical Design Prostacyclin, Atherothrombosis and Diabetes Mellitus: Physiologic and Clinical Considerations
Current Molecular Medicine Vitamin D in Acute Kidney Injury
Inflammation & Allergy - Drug Targets (Discontinued)