Abstract
Chitosan is a natural polysaccharide which is generally biodegradable, biocompatible and mucoadhesive, thus, attracting considerable interest of scientific researchers. The application of chitosan as nanocarriers for drug delivery thrived. And some of their pharmacokinetics and biodistribution profiles were studied, which are crucial to develop a promising drug delivery system. In this article, we will first give an introduction for the chitosan as drug delivery system, especially as nanoparticles. Then, we focus on pharmacokinetics studies of various chitosan nanoparticles both in vitro and in vivo. In a following part, we refer to researches on biodistribution properties of chitosan nanoparticles. Here we crucially discuss the in vivo fate of chitosan nanoparticles. And finally, toxicity issue is discussed and conclusions are drawn.
Keywords: Biodistribution, chitosan, delivery, in vivo, nanoparticles, pharmacokinetics
Current Drug Metabolism
Title:Pharmacokinetics and In Vivo Fate of Drug Loaded Chitosan Nanoparticles++
Volume: 13 Issue: 4
Author(s): Xiawei Wei, Zhirong Zhang and Zhiyong Qian
Affiliation:
Keywords: Biodistribution, chitosan, delivery, in vivo, nanoparticles, pharmacokinetics
Abstract: Chitosan is a natural polysaccharide which is generally biodegradable, biocompatible and mucoadhesive, thus, attracting considerable interest of scientific researchers. The application of chitosan as nanocarriers for drug delivery thrived. And some of their pharmacokinetics and biodistribution profiles were studied, which are crucial to develop a promising drug delivery system. In this article, we will first give an introduction for the chitosan as drug delivery system, especially as nanoparticles. Then, we focus on pharmacokinetics studies of various chitosan nanoparticles both in vitro and in vivo. In a following part, we refer to researches on biodistribution properties of chitosan nanoparticles. Here we crucially discuss the in vivo fate of chitosan nanoparticles. And finally, toxicity issue is discussed and conclusions are drawn.
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Cite this article as:
Wei Xiawei, Zhang Zhirong and Qian Zhiyong, Pharmacokinetics and In Vivo Fate of Drug Loaded Chitosan Nanoparticles++, Current Drug Metabolism 2012; 13 (4) . https://dx.doi.org/10.2174/138920012800166580
DOI https://dx.doi.org/10.2174/138920012800166580 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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