Abstract
In the search for appropriate models for Alzheimer’s disease (AD) involving animals other than rodents, several laboratories are working with animals that naturally develop cognitive dysfunction. Among the animals tested, dogs are quite unique in helping to elucidate the cascade of events that take place in brain amyloid-beta (Aβ)deposition aging, and cognitive deficit. Recent innovative research has validated human methods and tools for the analysis of canine neuropathology and has allowed the development of two different approaches to investigate dogs as natural models of AD. The first approach relates AD-like neuropathy with the decline in memory and learning ability in aged housed dogs in a highly controlled laboratory environment. The second approach involves research in family-owned animals with cognitive dysfunction syndrome. In this review, we compare the strengths and limitations of housed and family-owned canine models, and appraise their usefulness for deciphering the early mechanisms of AD and developing innovative therapies.
Keywords: Aging, amyloid-beta, animal model, canine cognitive dysfunction syndrome, family dog, therapies
Current Alzheimer Research
Title:Dogs with Cognitive Dysfunction Syndrome: A Natural Model of Alzheimer’s Disease
Volume: 9 Issue: 3
Author(s): Maria Neus Bosch, Marco Pugliese, Javier Gimeno-Bayon, Manuel Jose Rodriguez and Nicole Mahy
Affiliation:
Keywords: Aging, amyloid-beta, animal model, canine cognitive dysfunction syndrome, family dog, therapies
Abstract: In the search for appropriate models for Alzheimer’s disease (AD) involving animals other than rodents, several laboratories are working with animals that naturally develop cognitive dysfunction. Among the animals tested, dogs are quite unique in helping to elucidate the cascade of events that take place in brain amyloid-beta (Aβ)deposition aging, and cognitive deficit. Recent innovative research has validated human methods and tools for the analysis of canine neuropathology and has allowed the development of two different approaches to investigate dogs as natural models of AD. The first approach relates AD-like neuropathy with the decline in memory and learning ability in aged housed dogs in a highly controlled laboratory environment. The second approach involves research in family-owned animals with cognitive dysfunction syndrome. In this review, we compare the strengths and limitations of housed and family-owned canine models, and appraise their usefulness for deciphering the early mechanisms of AD and developing innovative therapies.
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Cite this article as:
Neus Bosch Maria, Pugliese Marco, Gimeno-Bayon Javier, Jose Rodriguez Manuel and Mahy Nicole, Dogs with Cognitive Dysfunction Syndrome: A Natural Model of Alzheimer’s Disease, Current Alzheimer Research 2012; 9 (3) . https://dx.doi.org/10.2174/156720512800107546
DOI https://dx.doi.org/10.2174/156720512800107546 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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