Abstract
New-generation antidepressants are a heterogeneous class of drugs used in the treatment of depression and related disorders. This review deals with the first new-generation antidepressant class to enter the pharmaceutical market, i.e., selective serotonin reuptake inhibitors (SSRIs), which are still the most prescribed and widely used ones. Their common characteristics are the comparable clinical efficacy, good tolerability and relative safety in comparison to “first generation antidepressants”, i.e. classic tricyclic antidepressants and monoamine oxidase inhibitors. This class of drugs includes fluoxetine, citalopram, paroxetine, sertraline, fluvoxamine and, since 2011, vilazodone.
In this review, the main pharmacodynamic and pharmacokinetic properties of the six commercially available SSRIs are described, focusing on side and toxic effects, chemical-clinical correlations, interactions with other drugs, the role of therapeutic drug monitoring (TDM) and related bioanalytical methodologies.
Keywords: Antidepressants, chemical-clinical correlations, pharmacological properties, selective serotonin reuptake inhibitors (SSRIs), therapeutic drug monitoring (TDM), fluoxetine, citalopram, paroxetine, sertraline, fluvoxamine, vilazodone
Current Medicinal Chemistry
Title:Selective Serotonin Reuptake Inhibitors (SSRIs): Therapeutic Drug Monitoring and Pharmacological Interactions
Volume: 19 Issue: 12
Author(s): R. Mandrioli, L. Mercolini, M. A. Saracino and M. A. Raggi
Affiliation:
Keywords: Antidepressants, chemical-clinical correlations, pharmacological properties, selective serotonin reuptake inhibitors (SSRIs), therapeutic drug monitoring (TDM), fluoxetine, citalopram, paroxetine, sertraline, fluvoxamine, vilazodone
Abstract: New-generation antidepressants are a heterogeneous class of drugs used in the treatment of depression and related disorders. This review deals with the first new-generation antidepressant class to enter the pharmaceutical market, i.e., selective serotonin reuptake inhibitors (SSRIs), which are still the most prescribed and widely used ones. Their common characteristics are the comparable clinical efficacy, good tolerability and relative safety in comparison to “first generation antidepressants”, i.e. classic tricyclic antidepressants and monoamine oxidase inhibitors. This class of drugs includes fluoxetine, citalopram, paroxetine, sertraline, fluvoxamine and, since 2011, vilazodone.
In this review, the main pharmacodynamic and pharmacokinetic properties of the six commercially available SSRIs are described, focusing on side and toxic effects, chemical-clinical correlations, interactions with other drugs, the role of therapeutic drug monitoring (TDM) and related bioanalytical methodologies.
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Cite this article as:
Mandrioli R., Mercolini L., A. Saracino M. and A. Raggi M., Selective Serotonin Reuptake Inhibitors (SSRIs): Therapeutic Drug Monitoring and Pharmacological Interactions, Current Medicinal Chemistry 2012; 19 (12) . https://dx.doi.org/10.2174/092986712800099749
DOI https://dx.doi.org/10.2174/092986712800099749 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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