Abstract
Cell-based therapies are a novel approach for regeneration of microvasculature. We have shown that administration of CD34-positive cells, the rich cell fraction of endothelial progenitor cells, after stroke induces angiogenesis that results in enhanced endogenous neurogenesis and functional recovery in a murine model. Moreover, injury-induced neurogenesis occurs in the human brain following a stroke during the acute to sub-acute period. Based on these observations, clinical trials of cell therapies that aim to regenerate micro-circulation in the brain following a stroke are ongoing worldwide. This review summarizes the current basic research findings about the link between angiogenesis and neurogenesis in the post-stroke brain and introduces the ongoing clinical trials of cell-based therapies for patients that have suffered a stroke.
Keywords: Angiogenesis, neurogenesis, stroke, neural stem cells, CD34-positive cells
Current Vascular Pharmacology
Title:Cell-Based Therapy to Promote Angiogenesis in the Brain Following Ischemic Damage
Volume: 10 Issue: 3
Author(s): Masahiro Uemura, Yukiko Kasahara, Kazuyuki Nagatsuka and Akihiko Taguchi
Affiliation:
Keywords: Angiogenesis, neurogenesis, stroke, neural stem cells, CD34-positive cells
Abstract: Cell-based therapies are a novel approach for regeneration of microvasculature. We have shown that administration of CD34-positive cells, the rich cell fraction of endothelial progenitor cells, after stroke induces angiogenesis that results in enhanced endogenous neurogenesis and functional recovery in a murine model. Moreover, injury-induced neurogenesis occurs in the human brain following a stroke during the acute to sub-acute period. Based on these observations, clinical trials of cell therapies that aim to regenerate micro-circulation in the brain following a stroke are ongoing worldwide. This review summarizes the current basic research findings about the link between angiogenesis and neurogenesis in the post-stroke brain and introduces the ongoing clinical trials of cell-based therapies for patients that have suffered a stroke.
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Cite this article as:
Uemura Masahiro, Kasahara Yukiko, Nagatsuka Kazuyuki and Taguchi Akihiko, Cell-Based Therapy to Promote Angiogenesis in the Brain Following Ischemic Damage, Current Vascular Pharmacology 2012; 10 (3) . https://dx.doi.org/10.2174/157016112799959369
DOI https://dx.doi.org/10.2174/157016112799959369 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
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