Abstract
Anthracyclines, such as doxorubicin and idarubicin, remain an important class of chemotherapeutic agents. Unfortunately, their efficacy in treating cancer is limited by a cumulative dose-dependent cardiotoxicity, which can cause irreversible heart failure. In this review, we discuss the pathogenesis and incidence of anthracycline-induced cardiotoxicity as well as methods to detect, prevent and treat the condition.
Keywords: Left ventricular dysfunction, doxorubicin, oxidant stress.
Current Cardiology Reviews
Title:Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment
Volume: 7 Issue: 4
Author(s): Maria Volkova and Raymond Russell
Affiliation:
Keywords: Left ventricular dysfunction, doxorubicin, oxidant stress.
Abstract: Anthracyclines, such as doxorubicin and idarubicin, remain an important class of chemotherapeutic agents. Unfortunately, their efficacy in treating cancer is limited by a cumulative dose-dependent cardiotoxicity, which can cause irreversible heart failure. In this review, we discuss the pathogenesis and incidence of anthracycline-induced cardiotoxicity as well as methods to detect, prevent and treat the condition.
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Cite this article as:
Volkova Maria and Russell Raymond, Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment, Current Cardiology Reviews 2011; 7 (4) . https://dx.doi.org/10.2174/157340311799960645
DOI https://dx.doi.org/10.2174/157340311799960645 |
Print ISSN 1573-403X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6557 |
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