Abstract
Synthesis and in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Ra and H37Rv of a number of 3-hydroxy[2,3-c][1]benzopyran-6(H)-ones 1a-f and 3-Benzyl-8-hydroxy-1,2,3,4-tetrahydro-chromeno[3,4- c]pyridin-5-ones 8a-c has been reported. Few of the compounds exhibited anti–tubercular activity with MIC as low as 3.12 μg/ml in virulent and avirulent strains.
Keywords: BACTEC, Coumarin, MDR tuberculosis, pechman condensation, triarylmethanes, tuberculosis, BCG, Benzofurans, ANTI-TUBERCULAR ACTIVITY, DMAP
Anti-Infective Agents
Title: Synthesis and Anti-tubercular Activities of Benzo[4,5]furo[2,3-c] Chromen -6-one Derivatives
Volume: 10 Issue: 1
Author(s): Noopur Srivastava, K. S. Anil Kumar, Sudhir Sinha, Ranjana Srivastava and D. K. Dikshit
Affiliation:
Keywords: BACTEC, Coumarin, MDR tuberculosis, pechman condensation, triarylmethanes, tuberculosis, BCG, Benzofurans, ANTI-TUBERCULAR ACTIVITY, DMAP
Abstract: Synthesis and in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Ra and H37Rv of a number of 3-hydroxy[2,3-c][1]benzopyran-6(H)-ones 1a-f and 3-Benzyl-8-hydroxy-1,2,3,4-tetrahydro-chromeno[3,4- c]pyridin-5-ones 8a-c has been reported. Few of the compounds exhibited anti–tubercular activity with MIC as low as 3.12 μg/ml in virulent and avirulent strains.
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Cite this article as:
Srivastava Noopur, Anil Kumar K. S., Sinha Sudhir, Srivastava Ranjana and Dikshit D. K., Synthesis and Anti-tubercular Activities of Benzo[4,5]furo[2,3-c] Chromen -6-one Derivatives, Anti-Infective Agents 2012; 10 (1) . https://dx.doi.org/10.2174/2211362611201010006
DOI https://dx.doi.org/10.2174/2211362611201010006 |
Print ISSN 2211-3525 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-3533 |
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