Abstract
There have been encouraging recent successes in the development of safe and effective topical microbicides to prevent vaginal or rectal HIV-1 transmission, based on the use of anti-retroviral drugs. However, much work remains to be accomplished before a microbicide becomes a standard element of prevention science strategies. Animal models should continue to play an important role in pre-clinical testing, with emphasis on safety, pharmacokinetic and efficacy testing.
Keywords: HIV, animal models, HIV transmission, mucosal transmission, vagina, rectum, microbicide, culture, cells, therapy
Current HIV Research
Title: Animal Models for Microbicide Studies
Volume: 10 Issue: 1
Author(s): Ronald S. Veazey, Robin J Shattock, Per Johan Klasse and John P. Moore
Affiliation:
Keywords: HIV, animal models, HIV transmission, mucosal transmission, vagina, rectum, microbicide, culture, cells, therapy
Abstract: There have been encouraging recent successes in the development of safe and effective topical microbicides to prevent vaginal or rectal HIV-1 transmission, based on the use of anti-retroviral drugs. However, much work remains to be accomplished before a microbicide becomes a standard element of prevention science strategies. Animal models should continue to play an important role in pre-clinical testing, with emphasis on safety, pharmacokinetic and efficacy testing.
Export Options
About this article
Cite this article as:
S. Veazey Ronald, J Shattock Robin, Johan Klasse Per and P. Moore John, Animal Models for Microbicide Studies, Current HIV Research 2012; 10 (1) . https://dx.doi.org/10.2174/157016212799304715
DOI https://dx.doi.org/10.2174/157016212799304715 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
Management of HIV: Management of HIV: old challenges and new needs
The aim of this thematic issue is to provide the most recent updates regarding the effective management of HIV infection. Antiretroviral therapy (ART) has significantly decreased HIV-related mortality, leading to an enhancement in the quality of life and life expectancy for people living with HIV (PLWH). Despite the numerous advancements ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers