Recent Advances in Asymmetric Membrane Capsule Based Osmotic Pump: A Patent Overview

Alpesh      Patel; Tarak      Mehta; Jimish      Patel; Mukesh      Patel; Kanu      Patel; Natvarlal      Patel

Abstract

Conventional drug delivery systems have little control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the process of osmosis. Osmotic devices are the most promising strategy based systems for controlled drug delivery. They are the most reliable controlled drug delivery systems and could be employed as oral drug delivery systems. The present review is concerned with the study of drug release through asymmetric membrane capsule systems. When these systems are exposed to water, low levels of water soluble additive are leached from polymeric material i.e. the semipermeable membrane and the drug releases in a controlled manner over an extended period of time. Drug delivery from this system is not influenced by the different physiological factors within the gut lumen and the release characteristics can be predicted easily from the known properties of the drug and the dosage form. This patent review is useful in the knowledge of asymmetric membrane capsule osmotic pump for its application.

Keywords: Asymmetric membrane capsule, osmogent, osmotic pump, semipermeable membrane, ASYMMETRICAL CAPSULE, osmotic system, solid lipid nanoparticles, OSMOTIC DRUG DELIVERY, sustained delivery, Phenylephrine Hydrochloride