Abstract
Interleukin-1β (IL-1β) has been implicated in many inflammatory and autoimmune diseases. Its role in pain, however, is under-appreciated. This may in part be due to the challenges involved in approaching the target from a therapeutic stand point. The scope of this brief review is to understand the direct and indirect roles of IL-1β in contributing to different pain states including inflammatory and neuropathic pain, and discuss approaches to block IL-1β production or IL-1 interactions.
Keywords: Interleukin-1, inflammation, pain, neuropathy, analgesic, hyperalgesia, P2X7, Spinal Nerve Ligation, Complex Regional Pain Syndrome, XOMA
CNS & Neurological Disorders - Drug Targets
Title: Targeting Interleukin-1β for Pain
Volume: 10 Issue: 5
Author(s): Sivaram Pillarisetti
Affiliation:
Keywords: Interleukin-1, inflammation, pain, neuropathy, analgesic, hyperalgesia, P2X7, Spinal Nerve Ligation, Complex Regional Pain Syndrome, XOMA
Abstract: Interleukin-1β (IL-1β) has been implicated in many inflammatory and autoimmune diseases. Its role in pain, however, is under-appreciated. This may in part be due to the challenges involved in approaching the target from a therapeutic stand point. The scope of this brief review is to understand the direct and indirect roles of IL-1β in contributing to different pain states including inflammatory and neuropathic pain, and discuss approaches to block IL-1β production or IL-1 interactions.
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Cite this article as:
Pillarisetti Sivaram, Targeting Interleukin-1β for Pain, CNS & Neurological Disorders - Drug Targets 2011; 10 (5) . https://dx.doi.org/10.2174/187152711796234998
DOI https://dx.doi.org/10.2174/187152711796234998 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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