Pharmacological Properties of Thalidomide and its Analogues

Title: Pharmacological Properties of Thalidomide and its Analogues

Volume: 4 Issue: 2

Author(s): Juan B. De Sanctis, Michael Mijares, Alirica Suarez, Reinaldo Compagnone, Jenny Garmendia, Dolores Moreno and Margarita Salazar-Bookaman

Affiliation:

Keywords: Thalidomide, IMiDs, lenalidomide, revlimid, actimid, pomalidomide, cytokines, Multiple myeloma, Prostate cancer, Angiogenesis, Diabetes

Abstract: Thalidomide and its immunomodulatory imide drugs (IMiDs) analogues CC-5013 (Revlimid™, Lenalidomide) and CC-4047 (Actimid™, Pomalidomide) have been used as anti-inflammatory and anticancerous drugs in the recent years. Thalidomide and IMiDs inhibit the cytokines tumour necrosis factor-α (TNF-α), interleukins (IL) 1β, 6, 12, and granulocyte macrophage-colony stimulating factor (GM-CSF). They also costimulate primary human T, NKT and NK lymphocytes inducing their proliferation, cytokine production, and cytotoxic activity. On the other hand, the compounds are anti-angiogenic, anti-proliferative, and pro-apoptotic. Thalidomide analogues have been used as inhibitors of α glucosidase and could be potential drugs for diabetes treatment. In this review, we explore the current trend of the different structures, the new patents, and the possible new applications in different pathologies.

Cite this article as:

B. De Sanctis Juan, Mijares Michael, Suarez Alirica, Compagnone Reinaldo, Garmendia Jenny, Moreno Dolores and Salazar-Bookaman Margarita, Pharmacological Properties of Thalidomide and its Analogues, Recent Patents on Inflammation & Allergy Drug Discovery 2010; 4 (2) . https://dx.doi.org/10.2174/187221310791163026