Abstract
Gankyrin, a newly defined oncoprotein also known as PSMD10 and P28, functions as a dual-negative regulator of the two most prominent tumor suppressor pathways, the CDK/pRb and MDM2/P53 pathways. Its aberrant expression has been prevalently found in human hepatocellular carcinomas (HCC) and esophagus squamous cell carcinomas (ESCC), indicative of the potential of gankyrin as a rational diagnostic and therapeutic target in cancers. Here, we review the unique structural features and functional diversity of gankyrin, and discuss its implication in cancer diagnostics and therapeutics from the perspective of chemical biology.
Keywords: Structure and function, gankyrin, oncoprotein, cancer
Current Chemical Biology
Title: Gankyrin Oncoprotein: Structure, Function, and Involvement in Cancer
Volume: 4 Issue: 1
Author(s): Junan Li and Yi Guo
Affiliation:
Keywords: Structure and function, gankyrin, oncoprotein, cancer
Abstract: Gankyrin, a newly defined oncoprotein also known as PSMD10 and P28, functions as a dual-negative regulator of the two most prominent tumor suppressor pathways, the CDK/pRb and MDM2/P53 pathways. Its aberrant expression has been prevalently found in human hepatocellular carcinomas (HCC) and esophagus squamous cell carcinomas (ESCC), indicative of the potential of gankyrin as a rational diagnostic and therapeutic target in cancers. Here, we review the unique structural features and functional diversity of gankyrin, and discuss its implication in cancer diagnostics and therapeutics from the perspective of chemical biology.
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Cite this article as:
Li Junan and Guo Yi, Gankyrin Oncoprotein: Structure, Function, and Involvement in Cancer, Current Chemical Biology 2010; 4 (1) . https://dx.doi.org/10.2174/2212796811004010013
DOI https://dx.doi.org/10.2174/2212796811004010013 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
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