Abstract
Amino acid mutations may have diverse effects on protein structure and function. Thus reliable information about the protein sequence variations is essential to gain insights into disease genotype-phenotype correlations. With the recent availability of the complete genome sequence and the accumulation of variation data, determining the effects of amino acid substitution will be the next challenge in mutation research. The molecular consequences of amino acid mutations can readily be predicted by numerous bioinformatic methods, which analyze the mutation effects from different points of view. In this review, these approaches are categorized according to their analysis principles. The applicability of these tools for inference of mutation-structure-function relationship is also recapitulated. When the human diseases are likely to involve defects in multiple genes, most of the current mutation analysis focuses on single point mutation and lacks an expansive proteome-wide perspective. We propose in this review the application of the existing computational tools in the analysis of correlated mutations at a system level. Directions for future developments and implications are discussed, which will help to understand the networks underlying human disease.
Keywords: Proteome, amino acid mutation, computational analysis, missense mutation, multiple sequence alignment
Current Proteomics
Title: Computational Analysis of Amino Acid Mutation: A Proteome Wide Perspective
Volume: 6 Issue: 4
Author(s): Jiajia Chen and Bairong Shen
Affiliation:
Keywords: Proteome, amino acid mutation, computational analysis, missense mutation, multiple sequence alignment
Abstract: Amino acid mutations may have diverse effects on protein structure and function. Thus reliable information about the protein sequence variations is essential to gain insights into disease genotype-phenotype correlations. With the recent availability of the complete genome sequence and the accumulation of variation data, determining the effects of amino acid substitution will be the next challenge in mutation research. The molecular consequences of amino acid mutations can readily be predicted by numerous bioinformatic methods, which analyze the mutation effects from different points of view. In this review, these approaches are categorized according to their analysis principles. The applicability of these tools for inference of mutation-structure-function relationship is also recapitulated. When the human diseases are likely to involve defects in multiple genes, most of the current mutation analysis focuses on single point mutation and lacks an expansive proteome-wide perspective. We propose in this review the application of the existing computational tools in the analysis of correlated mutations at a system level. Directions for future developments and implications are discussed, which will help to understand the networks underlying human disease.
Export Options
About this article
Cite this article as:
Chen Jiajia and Shen Bairong, Computational Analysis of Amino Acid Mutation: A Proteome Wide Perspective, Current Proteomics 2009; 6 (4) . https://dx.doi.org/10.2174/157016409789973734
DOI https://dx.doi.org/10.2174/157016409789973734 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
Call for Papers in Thematic Issues
Mass spectrometry data acquisition and analysis for proteomics
The Thematic Issue on "Mass spectrometry data acquisition and analysis for proteomics" aims to explore the latest advancements and challenges in the field of proteomics through the lens of mass spectrometry. Proteomics, the large-scale study of proteins and their functions, plays a crucial role in understanding various biological processes and ...read more
Peptides: State-of-Art and Commercialisation Hurdles
The Editors of the Current Proteomics (CP) journal are highly privileged to welcome scientists to submit their scientific research and review articles to be considered for publication in the upcoming thematic issue. The topics should cover various aspects of peptides in regard to their synthetic methodologies, formulation approaches, pharmacological challenges, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Quest for Surrogate Markers of Angiogenesis: A Paradigm for Translational Research in Tumor Angiogenesis and Anti- Angiogenesis Trials
Current Molecular Medicine Targeting Histone Onco- Modifications Using Plant-Derived Products
Current Drug Targets Metastasis: Recent Discoveries and Novel Perioperative Treatment Strategies with Particular Interest in the Hemostatic Compound Desmopressin
Current Pharmaceutical Biotechnology Regulation of Angiogenesis by the Small Heat Shock Protein αB-Crystallin
Current Angiogenesis (Discontinued) Ketogenic Diet and Other Dietary Intervention Strategies in the Treatment of Cancer
Current Medicinal Chemistry A Novel 99mTc-labeled Diphosphonic Acid as Potential Bone Seeking Agent: Synthesis and Biological Evaluation
Current Radiopharmaceuticals Histone Deacetylase Inhibitors: Potent Anti-Leukemic Agents
Current Medicinal Chemistry Counteraction of Skin Inflammation and Aging or Cancer by Polyphenols and Flavonoids from Polypodium leucotomos and Xanthohumol
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Enhancing Endothelial Progenitor Cell Function Through Selective Estrogen Receptor Modulation: A Potential Approach to Cardiovascular Risk Reduction
Cardiovascular & Hematological Agents in Medicinal Chemistry Review of the Contribution of Radiolabelled Tracers for Tumour Cell Status Imaging
Current Medical Imaging Polymorphisms of Human N-Acetyltransferases and Cancer Risk
Current Drug Metabolism Advances in Targeting Insulin-like Growth Factor Signaling Pathway in Cancer Treatment
Current Pharmaceutical Design Curcumin Targets Circulating Cancer Stem Cells by Inhibiting Self-Renewal Efficacy in Non-Small Cell Lung Carcinoma
Anti-Cancer Agents in Medicinal Chemistry General Molecular Biology and Architecture of Nuclear Receptors
Current Topics in Medicinal Chemistry miR-203 Suppresses the Proliferation and Metastasis of Hepatocellular Carcinoma by Targeting Oncogene ADAM9 and Oncogenic Long Non-coding RNA HULC
Anti-Cancer Agents in Medicinal Chemistry Histone Variants and Composition in the Developing Brain: Should MeCP2 Care?
Current Topics in Medicinal Chemistry Monosaccharide Compositional Analysis of Glycoproteins Using Liquid Chromatography-Mass Spectrometry
Current Proteomics Biologic Therapies in Primary Sjögren's Syndrome
Current Pharmaceutical Biotechnology Synthesis of [<sup>64</sup>Cu]Cu-NOTA-Bn-GE11 for PET Imaging of EGFR-Rich Tumors
Current Radiopharmaceuticals Pro-apoptotic Activity of BH3-only Proteins and BH3 Mimetics: from Theory to Potential Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry