Abstract
A 43 year old man with HIV and HCV infection and liver cirrhosis developed fatal lactic acidosis within five days from starting nifedipine for arterial hypertension. Multiple drug interactions, current and accumulated drug toxicities and the reduced liver function, might in combination have led to the acute lactic acidosis.
Keywords: Lactic acidosis, nifedipine, disulfiram, amitriptyline, ritonavir, HIV
Drug Metabolism Letters
Title: Fatal Lactic Acidosis Precipitated by Nifedipine in a Patient Treated with Disulfiram and Antiretrovirals
Volume: 3 Issue: 3
Author(s): Oswald Moling, Giovanni Rimenti, Raffaele Pristera, Claudio Vedovelli, Leonardo Pagani, Greta Spoladore and Peter Mian
Affiliation:
Keywords: Lactic acidosis, nifedipine, disulfiram, amitriptyline, ritonavir, HIV
Abstract: A 43 year old man with HIV and HCV infection and liver cirrhosis developed fatal lactic acidosis within five days from starting nifedipine for arterial hypertension. Multiple drug interactions, current and accumulated drug toxicities and the reduced liver function, might in combination have led to the acute lactic acidosis.
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Cite this article as:
Moling Oswald, Rimenti Giovanni, Pristera Raffaele, Vedovelli Claudio, Pagani Leonardo, Spoladore Greta and Mian Peter, Fatal Lactic Acidosis Precipitated by Nifedipine in a Patient Treated with Disulfiram and Antiretrovirals, Drug Metabolism Letters 2009; 3 (3) . https://dx.doi.org/10.2174/187231209789352120
DOI https://dx.doi.org/10.2174/187231209789352120 |
Print ISSN 1872-3128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-0758 |
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