Abstract
Cerebrovascular disease (CVD) has early been recognized in HIV-infected patients, including infectious arteritis, inflammatory vasculitis, aneurismal and small-vessel arteriopathy, to which adds now the premature atherosclerotic cerebral arteriopathy associated with the highly active antiretroviral therapy (HAART)-induced metabolic disorders. As a result of the increased life-expectancy associated with HAART, HIV patients grow older and are exposed to the combined vascular risk of antiviral-induced metabolic changes and advancing age. Several studies have documented subclinical cervical artery atherosclerosis, as assessed by intima-media thickness, ultrasound detection of carotid artery plaques and intracerebral small-vessel disease, all being associated with the induced metabolic changes. This suggests that vascular prevention should be performed on a long-term basis.
Keywords: HIV, AIDS, Stroke, Cerebrovascular disease
Current HIV Research
Title: Cerebrovascular Diseases in HIV-Infected Patients
Volume: 7 Issue: 5
Author(s): Jean-Jacques Monsuez, Colette Goujon, Benjamin Wyplosz, Carine Couzigou, Lelia Escaut and Daniel Vittecoq
Affiliation:
Keywords: HIV, AIDS, Stroke, Cerebrovascular disease
Abstract: Cerebrovascular disease (CVD) has early been recognized in HIV-infected patients, including infectious arteritis, inflammatory vasculitis, aneurismal and small-vessel arteriopathy, to which adds now the premature atherosclerotic cerebral arteriopathy associated with the highly active antiretroviral therapy (HAART)-induced metabolic disorders. As a result of the increased life-expectancy associated with HAART, HIV patients grow older and are exposed to the combined vascular risk of antiviral-induced metabolic changes and advancing age. Several studies have documented subclinical cervical artery atherosclerosis, as assessed by intima-media thickness, ultrasound detection of carotid artery plaques and intracerebral small-vessel disease, all being associated with the induced metabolic changes. This suggests that vascular prevention should be performed on a long-term basis.
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Cite this article as:
Monsuez Jean-Jacques, Goujon Colette, Wyplosz Benjamin, Couzigou Carine, Escaut Lelia and Vittecoq Daniel, Cerebrovascular Diseases in HIV-Infected Patients, Current HIV Research 2009; 7 (5) . https://dx.doi.org/10.2174/157016209789346345
DOI https://dx.doi.org/10.2174/157016209789346345 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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Management of HIV: Management of HIV: old challenges and new needs
The aim of this thematic issue is to provide the most recent updates regarding the effective management of HIV infection. Antiretroviral therapy (ART) has significantly decreased HIV-related mortality, leading to an enhancement in the quality of life and life expectancy for people living with HIV (PLWH). Despite the numerous advancements ...read more
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