Abstract
Plasmacytoid dendritic cells (pDC) play a key role in antiviral immunity through their immense capacity to produce type I interferons (IFN) and other cytokines and through induction of antigen-specific T cell responses. Several reports have documented decreased numbers and reduced function of pDC in the circulation of HIV patients associated with progression to disease, indicating that pDC are likely to be important in control of HIV infection. The mechanism of pDC loss has not been determined and is difficult to address in natural infection of humans. As highlighted in this brief review, the study of pDC dynamics in simian immunodeficiency virus (SIV) infection of nonhuman primates paves the way to understanding the complex biology of this important innate system cell in HIV and other viral infections.
Keywords: Plasmacytoid dendritic cells, migration, SIV, HIV, apoptosis, IFN-α
Current HIV Research
Title: Studies of Plasmacytoid Dendritic Cell Dynamics in Simian Immunodeficiency Virus Infection of Nonhuman Primates Provide Insights into HIV Pathogenesis
Volume: 7 Issue: 1
Author(s): Viskam Wijewardana, Kevin N. Brown and Simon M. Barratt-Boyes
Affiliation:
Keywords: Plasmacytoid dendritic cells, migration, SIV, HIV, apoptosis, IFN-α
Abstract: Plasmacytoid dendritic cells (pDC) play a key role in antiviral immunity through their immense capacity to produce type I interferons (IFN) and other cytokines and through induction of antigen-specific T cell responses. Several reports have documented decreased numbers and reduced function of pDC in the circulation of HIV patients associated with progression to disease, indicating that pDC are likely to be important in control of HIV infection. The mechanism of pDC loss has not been determined and is difficult to address in natural infection of humans. As highlighted in this brief review, the study of pDC dynamics in simian immunodeficiency virus (SIV) infection of nonhuman primates paves the way to understanding the complex biology of this important innate system cell in HIV and other viral infections.
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Cite this article as:
Wijewardana Viskam, Brown N. Kevin and Barratt-Boyes M. Simon, Studies of Plasmacytoid Dendritic Cell Dynamics in Simian Immunodeficiency Virus Infection of Nonhuman Primates Provide Insights into HIV Pathogenesis, Current HIV Research 2009; 7 (1) . https://dx.doi.org/10.2174/157016209787048483
DOI https://dx.doi.org/10.2174/157016209787048483 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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Management of HIV: Management of HIV: old challenges and new needs
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