Pharmacokinetic and Pharmacodynamic Predictions of Novel Potential HIV-1 Integrase Inhibitors

Title: Pharmacokinetic and Pharmacodynamic Predictions of Novel Potential HIV-1 Integrase Inhibitors

Volume: 2 Issue: 4

Author(s): C.H. T.P. da Silva, V.B. da Silva and C. A. Taft

Affiliation:

Keywords: Pharmacodynamic, HIV-1 Integrase Inhibitors, Virtual screening, metabolism, computational chemistry

Abstract: Virtual screening docking-based approach has been employed in order to select novel HIV-1 integrase (IN) potential inhibitors in large databases. Toxicity, metabolism and drug-like properties have been analyzed for the most promising compounds, using computational chemistry techniques. Results were compared and discussed with that obtained for a known HIV-1 (IN) inhibitor reported in the literature.

Cite this article as:

da Silva T.P. C.H., da Silva V.B. and Taft A. C., Pharmacokinetic and Pharmacodynamic Predictions of Novel Potential HIV-1 Integrase Inhibitors, Drug Metabolism Letters 2008; 2 (4) . https://dx.doi.org/10.2174/187231208786734102