Microsome Biocolloids for Rapid Drug Metabolism and in hibition Assessment by LC-MS

Title: Microsome Biocolloids for Rapid Drug Metabolism and in hibition Assessment by LC-MS

Volume: 2 Issue: 3

Author(s): Besnik Bajrami, Sadagopan Krishnan and James F. Rusling

Affiliation:

Keywords: Microsome-biocolloids, N-nitrosamines, inhibition, cap-LC/MS, CYP, Ketoconazole

Abstract: Rat liver microsomes attached to nanoparticles were used for LC-MS studies of CYP3A and 2E1 enzymes in metabolism of N -nitro so compounds.Using these biocolloids,turnover rates were measured within 2 min. Inhibitor IC 50 values for ketoconazole(KET) and 4-methylpyrazoie (4-MEP) were estimated.

Cite this article as:

Bajrami Besnik, Krishnan Sadagopan and Rusling F. James, Microsome Biocolloids for Rapid Drug Metabolism and in hibition Assessment by LC-MS, Drug Metabolism Letters 2008; 2 (3) . https://dx.doi.org/10.2174/187231208785425854