Abstract
Rat liver microsomes attached to nanoparticles were used for LC-MS studies of CYP3A and 2E1 enzymes in metabolism of N -nitro so compounds.Using these biocolloids,turnover rates were measured within 2 min. Inhibitor IC 50 values for ketoconazole(KET) and 4-methylpyrazoie (4-MEP) were estimated.
Keywords: Microsome-biocolloids, N-nitrosamines, inhibition, cap-LC/MS, CYP, Ketoconazole
Drug Metabolism Letters
Title: Microsome Biocolloids for Rapid Drug Metabolism and in hibition Assessment by LC-MS
Volume: 2 Issue: 3
Author(s): Besnik Bajrami, Sadagopan Krishnan and James F. Rusling
Affiliation:
Keywords: Microsome-biocolloids, N-nitrosamines, inhibition, cap-LC/MS, CYP, Ketoconazole
Abstract: Rat liver microsomes attached to nanoparticles were used for LC-MS studies of CYP3A and 2E1 enzymes in metabolism of N -nitro so compounds.Using these biocolloids,turnover rates were measured within 2 min. Inhibitor IC 50 values for ketoconazole(KET) and 4-methylpyrazoie (4-MEP) were estimated.
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Cite this article as:
Bajrami Besnik, Krishnan Sadagopan and Rusling F. James, Microsome Biocolloids for Rapid Drug Metabolism and in hibition Assessment by LC-MS, Drug Metabolism Letters 2008; 2 (3) . https://dx.doi.org/10.2174/187231208785425854
DOI https://dx.doi.org/10.2174/187231208785425854 |
Print ISSN 1872-3128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-0758 |
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