Abstract
The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug – drug interactions are likely to occur through either mechanism.
Keywords: protein binding, CYP isoforms, Hepatocytes, omeprazole, glucuronidation
Drug Metabolism Letters
Title: Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes
Volume: 2 Issue: 1
Author(s): Christa Kneip, Rolf Terlinden, Horst Beier and Genfu Chen
Affiliation:
Keywords: protein binding, CYP isoforms, Hepatocytes, omeprazole, glucuronidation
Abstract: The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug – drug interactions are likely to occur through either mechanism.
Export Options
About this article
Cite this article as:
Kneip Christa, Terlinden Rolf, Beier Horst and Chen Genfu, Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes, Drug Metabolism Letters 2008; 2 (1) . https://dx.doi.org/10.2174/187231208783478434
DOI https://dx.doi.org/10.2174/187231208783478434 |
Print ISSN 1872-3128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-0758 |
Related Articles
-
Catestatin: A Master Regulator of Cardiovascular Functions
Current Medicinal Chemistry Uric Acid and Oxidative Stress
Current Pharmaceutical Design Rifaximin: An Antibiotic with Important Biologic Effects
Mini-Reviews in Medicinal Chemistry Renal Effects of Non-Steroidal Anti-Inflammatory Drugs and Selective Cyclooxygenase-2 Inhibitors
Current Pharmaceutical Design Efficacy of Pentoxifylline in the Management of Microalbuminuria in Patients with Diabetes
Current Diabetes Reviews Resveratrol and Stroke: from Chemistry to Medicine
Current Neurovascular Research The G Protein β3 Subunit Gene (GNB3) 825T Allele - a Thrifty Genotype
Current Genomics Editorial from Editor-in-Chief (Hypoxic Pulmonary Hypertension: Are We Getting Closer to the Answer?)
Current Respiratory Medicine Reviews Herbal Drugs for Diabetic Treatment: An Updated Review of Patents
Recent Patents on Anti-Infective Drug Discovery Pharmacokinetic Mechanisms for Reduced Toxicity of Irinotecan by Coadministered Thalidomide
Current Drug Metabolism Aqueous Humor Pharmacokinetics of Dorzolamide Loaded PLGAChitosan Nanoparticles by Ultra Performance Liquid Chromatography
Current Pharmaceutical Analysis Acute Actions of Natriuretic Peptides in Coronary Vasculature and Ischaemic Myocardium
Current Pharmaceutical Design Nanowired Drug Delivery Across the Blood-Brain Barrier in Central Nervous System Injury and Repair
CNS & Neurological Disorders - Drug Targets Patent Selections
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery The role of NADPH Oxidase in Vascular Disease – Hypertension, Atherosclerosis & Stroke
Current Pharmaceutical Design Subject Index To Volume 4
Cardiovascular & Hematological Agents in Medicinal Chemistry Inhibitory Role of Resveratrol in the Development of Profibrogenesis and Fibrosis Mechanisms
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) The Impact of Maternal Voice on the Fetus: A Systematic Review
Current Women`s Health Reviews Antihyperglycemic and Antidyslipidemic Activities of the <i>Aqueous Salvia hispanica</i> Extract in Diabetic Rat
Cardiovascular & Hematological Agents in Medicinal Chemistry Anti-Inflammatory, Antibacterial and Analgesic Potential of Cocos Nucifera Linn.: A Review
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry