Abstract
Eicosanoids have been the major therapeutic targets in rheumatoid arthritis and other degenerative diseases where inflammation is involved. In the past decade, the biological significance of eicosanoids and their potential as therapeutic targets in cancer have also been recognized and is now a focal area of research in many laboratories. Recently, phospholipase A2 (PLA2), the enzyme responsible for arachidonic acid supply to eicosanoid-producing enzymes has attracted attention. It has been proposed that PLA2 inhibition can yield a better therapeutic outcome than inhibition of individual eicosanoid-producing enzymes. In this article, we focus on the rationale for targeting arachidonic acideicosanoid pathways as well as evaluate the recent patents that identify inhibitors of the PLA2 family of enzymes.
Keywords: Eicosanoids, cyclooxygenase, lipoxygenase, secreted phospholipase A2, cytosolic phospholipase A2, annexin A1, annexin A2
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Title: Aberrant Activation of Arachidonic Acid and Eicosanoid Pathways-Targets for Treating Prostate Cancer
Volume: 2 Issue: 1
Author(s): Qihan Dong, Marzieh Niknami, Manish Patel and Paul Witting
Affiliation:
Keywords: Eicosanoids, cyclooxygenase, lipoxygenase, secreted phospholipase A2, cytosolic phospholipase A2, annexin A1, annexin A2
Abstract: Eicosanoids have been the major therapeutic targets in rheumatoid arthritis and other degenerative diseases where inflammation is involved. In the past decade, the biological significance of eicosanoids and their potential as therapeutic targets in cancer have also been recognized and is now a focal area of research in many laboratories. Recently, phospholipase A2 (PLA2), the enzyme responsible for arachidonic acid supply to eicosanoid-producing enzymes has attracted attention. It has been proposed that PLA2 inhibition can yield a better therapeutic outcome than inhibition of individual eicosanoid-producing enzymes. In this article, we focus on the rationale for targeting arachidonic acideicosanoid pathways as well as evaluate the recent patents that identify inhibitors of the PLA2 family of enzymes.
Export Options
About this article
Cite this article as:
Dong Qihan, Niknami Marzieh, Patel Manish and Witting Paul, Aberrant Activation of Arachidonic Acid and Eicosanoid Pathways-Targets for Treating Prostate Cancer, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 2008; 2 (1) . https://dx.doi.org/10.2174/187221408783421291
DOI https://dx.doi.org/10.2174/187221408783421291 |
Print ISSN 1872-2148 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3334 |
Related Articles
-
New Therapeutic Strategies for Castration-Resistant Prostate Cancer
Recent Patents on Anti-Cancer Drug Discovery New Developments in Targeted Analysis of Protein Posttranslational Modifications
Current Proteomics 9-bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-11H-indeno[1, 2-c]quinolin-11-one (BPIQ), A Quinoline Derivative Inhibits Human Hepatocellular Carcinoma Cells by Inducing ER Stress and Apoptosis
Anti-Cancer Agents in Medicinal Chemistry CoMFA/CoMSIA and Molecular Docking Studies of Novel Matrix Metalloproteinase- 2 Inhibitors Based on L-tyrosine Scaffold
Letters in Drug Design & Discovery Zoledronic Acid Inhibits the RhoA-mediated Amoeboid Motility of Prostate Cancer Cells
Current Cancer Drug Targets Impaired Autophagy Mediates Resistance to Low-Dose Metronomic Cyclophosphamide Chemotherapy
Clinical Cancer Drugs Editorial (Hot Topic: Androgen Receptor and Prostate Cancer: New Insights in an Old Target Translate into Novel Therapeutic Strategies)
Current Drug Targets Current Protein-based Anti-angiogenic Therapeutics
Mini-Reviews in Medicinal Chemistry Streamlined In Vivo Selection and Screening of Human Prostate Carcinoma Avid Phage Particles for Development of Peptide Based In Vivo Tumor Imaging Agents
Combinatorial Chemistry & High Throughput Screening The PKB/AKT Pathway in Cancer
Current Pharmaceutical Design Estrogen Receptors as Therapeutic Targets in Breast Cancer
Current Topics in Medicinal Chemistry Role of the Cytoskeleton in Steroidogenesis
Endocrine, Metabolic & Immune Disorders - Drug Targets A Novel Treatment Strategy for Sepsis and Septic Shock Based on the Interactions between Prostanoids, Nitric Oxide, and 20-Hydroxyeicosatetraenoic Acid
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Extracellular Citrate in Health and Disease
Current Molecular Medicine Immunoregulatory and Effector Activities of Nitric Oxide and Reactive Nitrogen Species in Cancer
Current Medicinal Chemistry The Role of Melatonin in Multiple Sclerosis, Huntington's Disease and Cerebral Ischemia
CNS & Neurological Disorders - Drug Targets Hyaluronan and Hyaluronan Synthases: Potential Therapeutic Targets in Cancer
Current Drug Targets - Cardiovascular & Hematological Disorders T-Cell Zeta Chain Expression, Phosphorylation and Degradation and their Role in T-Cell Signal Transduction and Immune Response Regulation in Health And Disease
Current Signal Transduction Therapy Anticancer Activity and Mechanism Investigation of Beauvericin Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi
Anti-Cancer Agents in Medicinal Chemistry The Anti-cancer Actions of Vitamin D
Anti-Cancer Agents in Medicinal Chemistry