Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti- Inflammatory and Wound-Healing Promoting Metabolites

Title: Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti- Inflammatory and Wound-Healing Promoting Metabolites

Volume: 1 Issue: 4

Author(s): Christoph Wiesner, Jiri Kopecky, Maren Pflueger, Harald Hundsberger, Barbara Entler, Christoph Kleber, Josef Atzler, Pavel Hrouzek, Dalibor Stys, Alena Lukesova, Wolfgang Schuett and Rudolf Lucas

Affiliation:

Keywords: Nostoc, ARDS, endothelium, ICAM-1, Interleukin 8, wound-healing

Abstract: Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.

Cite this article as:

Wiesner Christoph, Kopecky Jiri, Pflueger Maren, Hundsberger Harald, Entler Barbara, Kleber Christoph, Atzler Josef, Hrouzek Pavel, Stys Dalibor, Lukesova Alena, Schuett Wolfgang and Lucas Rudolf, Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti- Inflammatory and Wound-Healing Promoting Metabolites, Drug Metabolism Letters 2007; 1 (4) . https://dx.doi.org/10.2174/187231207783221385