Abstract
In the lung, inflammation followed by the loss of epithelial cell precursors beyond a safeguard threshold, leads to increased mesenchymal repair and autonomous fibrosis. Fas-Fas ligand induced apoptosis promotes IL-1β secretion, neutrophil extravasation, and loss of epithelial cells. In models of lung disease, inflammation and fibrosis can be controled by interfering with either Fas-Fas ligand interaction, or with downstream caspase activation. These results suggest that the Fas-Fas ligand pathway is a target for the design of new therapeutic strategies for lung diseases.
Keywords: apoptosis, fas, inflammation, macrophage, lung, fibrosis, cell death, chemokines
Current Drug Targets - Inflammation & Allergy
Title: Role of Fas-Ligand Induced Apoptosis in Pulmonary Inflammation and Injury
Volume: 2 Issue: 2
Author(s): George A. DosReis and Valeria M. Borges
Affiliation:
Keywords: apoptosis, fas, inflammation, macrophage, lung, fibrosis, cell death, chemokines
Abstract: In the lung, inflammation followed by the loss of epithelial cell precursors beyond a safeguard threshold, leads to increased mesenchymal repair and autonomous fibrosis. Fas-Fas ligand induced apoptosis promotes IL-1β secretion, neutrophil extravasation, and loss of epithelial cells. In models of lung disease, inflammation and fibrosis can be controled by interfering with either Fas-Fas ligand interaction, or with downstream caspase activation. These results suggest that the Fas-Fas ligand pathway is a target for the design of new therapeutic strategies for lung diseases.
Export Options
About this article
Cite this article as:
DosReis A. George and Borges M. Valeria, Role of Fas-Ligand Induced Apoptosis in Pulmonary Inflammation and Injury, Current Drug Targets - Inflammation & Allergy 2003; 2 (2) . https://dx.doi.org/10.2174/1568010033484287
DOI https://dx.doi.org/10.2174/1568010033484287 |
Print ISSN 1568-010X |
Publisher Name Bentham Science Publisher |
Online ISSN 1568-010X |
Related Articles
-
Advances Towards The Discovery of GPR55 Ligands
Current Medicinal Chemistry Pharmacologic Strategies for Suppression of Lipid Peroxidation in Neurodegeneration
Current Neuropharmacology Myostatin Inhibition and Cardiometabolic Disorders
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) The Physiology of Nitric Oxide: Control and Consequences
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Mechanisms of Mononuclear Phagocyte Recruitment in Alzheimers Disease
CNS & Neurological Disorders - Drug Targets Fullerenes: From Carbon to Nanomedicine
Mini-Reviews in Medicinal Chemistry Osteoinductive Small Molecules: Growth Factor Alternatives for Bone Tissue Engineering
Current Pharmaceutical Design Preface
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) Ageing as a Trait de Union Between Diabetes and Dementia for Frailty
CNS & Neurological Disorders - Drug Targets Renal Innervation in Resistant Hypertension: A Review of Pathophysiology and Renal Denervation as Potential Treatment
Current Hypertension Reviews Cryptotanshinone Induces Necroptosis Through Ca<sup>2+</sup> Release and ROS Production <i>in vitro</i> and <i>in vivo</i>
Current Molecular Pharmacology Garcinia Benzophenones Inhibit the Growth of Human Colon Cancer Cells and Synergize with Sulindac Sulfide and Turmeric
Anti-Cancer Agents in Medicinal Chemistry Vitamin D : Autoimmunity and Gender
Current Medicinal Chemistry Community-Acquired Pneumonia in Children
Recent Patents on Inflammation & Allergy Drug Discovery Epratuzumab and Blinatumomab as Therapeutic Antibodies for Treatment of Pediatric Acute Lymphoblastic Leukemia: Current Status and Future Perspectives
Current Medicinal Chemistry Effect of miRNAs, Proinflammatory Cytokines and ACE2 in COVID-19 Pathophysiology
Coronaviruses Skin Barrier Dysfunction and Systemic Sensitization to Allergens Through the Skin
Current Drug Targets - Inflammation & Allergy Antidepressants: Update on Benefits and Risks
Current Psychopharmacology Predicted SARS-CoV-2 miRNAs Associated with Epigenetic Viral Pathogenesis and the Detection of New Possible Drugs for Covid-19
Current Drug Delivery Nerve Growth Factor in Alcohol Use Disorders
Current Neuropharmacology