Abstract
Crohns disease is an inflammatory bowel disease associated with several changes in the immune system, including an increased number of infiltrating macrophages. These macrophages release a variety of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), macrophage infiltrating factor (MIF), interleukin (IL)-6, IL-12 and IL-18, which are critically involved in the onset and the development of Crohns disease. We here focus on the role of macrophages, especially macrophagederived IL-18 in both patients with Crohns disease and a murine model of Crohns disease.
Keywords: crohns disease, proinflammatory cytokines, il-18, immunotoxin, targeting
Current Drug Targets - Inflammation & Allergy
Title: Macrophage-Derived IL-18 Targeting for the Treatment of Crohns Disease
Volume: 2 Issue: 2
Author(s): Takanori Kanai, Koji Uraushihara, Teruji Totsuka, Akira Okazawa, Toshifumi Hibi, Shigeru Oshima, Tatsuya Miyata, Tetsuya Nakamura and Mamoru Watanabe
Affiliation:
Keywords: crohns disease, proinflammatory cytokines, il-18, immunotoxin, targeting
Abstract: Crohns disease is an inflammatory bowel disease associated with several changes in the immune system, including an increased number of infiltrating macrophages. These macrophages release a variety of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), macrophage infiltrating factor (MIF), interleukin (IL)-6, IL-12 and IL-18, which are critically involved in the onset and the development of Crohns disease. We here focus on the role of macrophages, especially macrophagederived IL-18 in both patients with Crohns disease and a murine model of Crohns disease.
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Cite this article as:
Kanai Takanori, Uraushihara Koji, Totsuka Teruji, Okazawa Akira, Hibi Toshifumi, Oshima Shigeru, Miyata Tatsuya, Nakamura Tetsuya and Watanabe Mamoru, Macrophage-Derived IL-18 Targeting for the Treatment of Crohns Disease, Current Drug Targets - Inflammation & Allergy 2003; 2 (2) . https://dx.doi.org/10.2174/1568010033484250
DOI https://dx.doi.org/10.2174/1568010033484250 |
Print ISSN 1568-010X |
Publisher Name Bentham Science Publisher |
Online ISSN 1568-010X |
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